Summary: Scorpion short toxin, BmKK2
Scorpion short toxin, BmKK2 Provide feedback
Members of this family, which are found in various scorpion toxins, confer potassium channel blocking activity .
Zhang N, Li M, Chen X, Wang Y, Wu G, Hu G, Wu H; , Proteins. 2004;55:835-845.: Solution structure of BmKK2, a new potassium channel blocker from the venom of chinese scorpion Buthus martensi Karsch. PUBMED:15146482 EPMC:15146482
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This tab holds annotation information from the InterPro database.
InterPro entry IPR001947
Scorpion venoms contain a variety of peptides toxic to mammals, insects and crustaceans. Among these peptides there is a family of short toxins (30 to 40 residues) [PUBMED:7998956, PUBMED:7819188]. This entry represents members of this family with potassium channel blocking activity [PUBMED:15146482].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||extracellular region (GO:0005576)|
|Molecular function||ion channel inhibitor activity (GO:0008200)|
|Biological process||pathogenesis (GO:0009405)|
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This clan includes a number of toxin families that share the knottin structure. These families come from scorpions, plants and arthropods.
The clan contains the following 11 members:Defensin_2 DUF2667 Gamma-thionin SCRL SLR1-BP Toxin_17 Toxin_2 Toxin_3 Toxin_37 Toxin_38 Toxin_5
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Number in seed:||48|
|Number in full:||130|
|Average length of the domain:||31.00 aa|
|Average identity of full alignment:||44 %|
|Average coverage of the sequence by the domain:||65.14 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||14|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Toxin_2 domain has been found. There are 50 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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