Summary: Antifungal peptide termicin
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Antifungal peptide termicin Provide feedback
Termicin is a cysteine-rich antifungal peptide which exhibits antibacterial activity. A cysteine stabilised alpha beta motif is formed due to an alpha-helical segment and a two-stranded antiparallel beta-sheet .
Da Silva P, Jouvensal L, Lamberty M, Bulet P, Caille A, Vovelle F; , Protein Sci. 2003;12:438-446.: Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger. PUBMED:12592014 EPMC:12592014
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This tab holds annotation information from the InterPro database.
InterPro entry IPR024723
Termicin is a cysteine-rich antifungal peptide, which also exhibits weak antibacterial activity. The global fold of termicin consists of an alpha-helical segment and a two-stranded antiparallel beta-sheet forming a cysteine stabilised alphabeta motif that is also found in antibacterial and antifungal defensins from insects and from plants. The antifungal properties of termicin may be related to its marked hydrophobicity and its amphipatic structure compared to the antibacterial defensins [PUBMED:12592014].
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This clan includes a number of toxin families that share the knottin structure. These families come from scorpions, plants and arthropods.
The clan contains the following 11 members:Defensin_2 DUF2667 Gamma-thionin SCRL SLR1-BP Toxin_17 Toxin_2 Toxin_3 Toxin_37 Toxin_38 Toxin_5
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Curation and family details
|Number in seed:||8|
|Number in full:||150|
|Average length of the domain:||34.90 aa|
|Average identity of full alignment:||64 %|
|Average coverage of the sequence by the domain:||56.29 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Toxin_37 domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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