Summary: Potassium channel toxin
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This family includes scorpion potassium channel toxins [1-2].
Cao Z, Xiao F, Peng F, Jiang D, Mao X, Liu H, Li W, Hu D, Wang T;, Peptides. 2003;24:187-192.: Expression, purification and functional characterization of a recombinant scorpion venom peptide BmTXKbeta. PUBMED:12668201 EPMC:12668201
Rogowski RS, Krueger BK, Collins JH, Blaustein MP;, Proc Natl Acad Sci U S A. 1994;91:1475-1479.: Tityustoxin K alpha blocks voltage-gated noninactivating K+ channels and unblocks inactivating K+ channels blocked by alpha-dendrotoxin in synaptosomes. PUBMED:7509073 EPMC:7509073
This tab holds annotation information from the InterPro database.
InterPro entry IPR029237
This family consists of long chain scorpion potassium channel toxins [PUBMED:12668201, PUBMED:7509073] and scorpine-like peptides [PUBMED:23262394, PUBMED:15241551]. Scorpine-like peptides include scorpine, opiscorpine1-4, HgeScplp1, HgeScplp2 and heteroscorpine 1. They exhibit strong antimicrobial effects as well as cytolytic activity against eukaryotic cells [PUBMED:23262394].
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This clan includes a number of toxin families that share the knottin structure. These families come from scorpions, plants and arthropods.
The clan contains the following 13 members:BmKX Defensin_2 Defensin_like Gamma-thionin SCRL SLR1-BP Toxin_17 Toxin_2 Toxin_3 Toxin_37 Toxin_38 Toxin_5 Toxin_6
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Curation and family details
|Number in seed:||13|
|Number in full:||0|
|Average length of the domain:||0.00 aa|
|Average identity of full alignment:||0 %|
|Average coverage of the sequence by the domain:||0.00 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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