Summary: Clostridium neurotoxin, N-terminal receptor binding
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Clostridium neurotoxin, N-terminal receptor binding Provide feedback
The Clostridium neurotoxin family is composed of tetanus neurotoxin and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein. The N-terminal catalytic domain (PF01742), the central translocation domains and two receptor binding domains . This domains is the N-terminal receptor binding domain,which is comprised of two seven-stranded beta-sheets sandwiched together to form a jelly role motif . The role of this domain in receptor binding appears to be indirect.
This tab holds annotation information from the InterPro database.
InterPro entry IPR012928
The Clostridium neurotoxin family is composed of tetanus neurotoxin and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein. The N-terminal catalytic domain (INTERPRO), the central translocation domain and two receptor binding domains [PUBMED:9783750]. This domain is the N-terminal receptor binding domain, which is comprised of two seven-stranded beta-sheets sandwiched together to form a jelly role motif [PUBMED:9783750]. The role of this domain in receptor binding appears to be indirect.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||extracellular region (GO:0005576)|
|Molecular function||toxin receptor binding (GO:0050827)|
|metalloendopeptidase activity (GO:0004222)|
|Biological process||inhibition of neurotransmitter uptake (GO:0051609)|
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This superfamily includes a diverse range of carbohydrate binding domains and glycosyl hydrolase enzymes that share a common structure.
The clan contains the following 18 members:Cleaved_Adhesin DUF1080 DUF2401 Gal-bind_lectin Glyco_hydro_11 Glyco_hydro_12 Glyco_hydro_16 Glyco_hydro_7 Laminin_G_1 Laminin_G_2 Laminin_G_3 Lectin_leg-like Lectin_legB MAM Pentaxin Sialidase SKN1 Toxin_R_bind_N
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Curation and family details
|Seed source:||Pfam-B_1058 (release 15.0)|
|Number in seed:||13|
|Number in full:||10|
|Average length of the domain:||183.30 aa|
|Average identity of full alignment:||34 %|
|Average coverage of the sequence by the domain:||15.67 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
|Download:||download the raw HMM for this family|
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There are 6 interactions for this family. More...
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Toxin_R_bind_N domain has been found. There are 91 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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