Summary: Tryptophan/tyrosine permease family
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Tryptophan/tyrosine permease family Provide feedback
No Pfam abstract.
Martin K, Morlin G, Smith A, Nordyke A, Eisenstark A, Golomb M; , J Bacteriol 1998;180:107-118.: The tryptophanase gene cluster of Haemophilus influenzae type b: evidence for horizontal gene transfer. PUBMED:9422600 EPMC:9422600
Internal database links
|Similarity to PfamA using HHSearch:||Aa_trans AA_permease Spore_permease AA_permease_2|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR018227Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [PUBMED:3146645, PUBMED:2687114, PUBMED:8382989].
Aromatic amino acids are concentrated in the cytoplasm of Escherichia coli by 4 distinct transport systems: a general aromatic amino acid permease, and a specific permease for each of the 3 types (Phe, Tyr and Trp) [PUBMED:1987112]. It has been shown [PUBMED:2022620] that some permeases in E. coli and related bacteria are evolutionary related. These permeases are proteins of about 400 to 420 amino acids and are located in the cytoplasmic membrane and, like bacterial sugar/cation transporters, are thought to contain 12 transmembrane (TM) regions [PUBMED:1987112] - hydropathy analysis, however, is inconclusive, suggesting the possibility of 10 to 12 membrane-spanning domains [PUBMED:2022620]. The best conserved domain is a stretch of 20 residues which seems to be located in a cytoplasmic loop between the first and second transmembrane region.
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This large superfamily contains a variety of transporters including amino acid permeases that according to TCDB belong to the APC (Amino acid-Polyamine-organoCation) superfamily.
The clan contains the following 18 members:AA_permease AA_permease_2 AA_permease_C Aa_trans BenE Branch_AA_trans CstA HCO3_cotransp K_trans Na_Ala_symp Nramp Spore_permease SSF Sulfate_tra_GLY Sulfate_transp Transp_cyt_pur Trp_Tyr_perm Xan_ur_permease
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Curation and family details
|Seed source:||Pfam-B_2873 (release 6.5)|
|Number in seed:||13|
|Number in full:||4713|
|Average length of the domain:||382.30 aa|
|Average identity of full alignment:||25 %|
|Average coverage of the sequence by the domain:||94.07 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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