Summary: Tryptophan 2,3-dioxygenase
Tryptophan 2,3-dioxygenase Provide feedback
No Pfam abstract.
Comings DE, Muhleman D, Dietz G, Sherman M, Forest GL; , Genomics 1995;29:390-396.: Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat. PUBMED:8666386 EPMC:8666386
Internal database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR004981
|Molecular function||heme binding (GO:0020037)|
|tryptophan 2,3-dioxygenase activity (GO:0004833)|
|Biological process||tryptophan catabolic process to kynurenine (GO:0019441)|
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This example describes an architecture with one
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EGFdomains, and finally a single
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Curation and family details
|Seed source:||Pfam-B_4263 (release 6.5)|
|Number in seed:||5|
|Number in full:||1874|
|Average length of the domain:||179.80 aa|
|Average identity of full alignment:||25 %|
|Average coverage of the sequence by the domain:||85.05 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||12|
|Download:||download the raw HMM for this family|
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There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Trp_dioxygenase domain has been found. There are 89 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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