Summary: Tubulin domain
Tubulin domain Provide feedback
This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Misato from Drosophila and Dml1p from fungi are descendants of an ancestral tubulin-like protein, and exhibit regions with similarity to members of a GTPase family that includes eukaryotic tubulin and prokaryotic FtsZ. Dml1p and Misato have been co-opted into a role in mtDNA inheritance in yeast, and into a cell division-related mechanism in flies, respectively. Dml1p might additionally function in the partitioning of the mitochondrial organelle itself, or in the segregation of chromosomes, thereby explaining its essential requirement. This domain subject to extensive post-translational modifications.
Gurvitz A, Hartig A, Ruis H, Hamilton B, de Couet HG;, FEMS Yeast Res. 2002;2:123-135.: Preliminary characterisation of DML1, an essential Saccharomyces cerevisiae gene related to misato of Drosophila melanogaster. PUBMED:12702300 EPMC:12702300
Internal database links
|Similarity to PfamA using HHSearch:||Tubulin|
External database links
This tab holds annotation information from the InterPro database.
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- the number of sequences which exhibit this architecture
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This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
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This superfamily is characterised by being of alpha-beta two-layer sandwich structures. A segmental duplication early on in the primate lineage has led to the creation of up to three tubulin-like domains in the higher primates. The most N-terminal one is the Misato domain, which probably represents the original domain .
The clan contains the following 6 members:FtsZ_C Misat_Tub_SegII Tubulin Tubulin_2 Tubulin_3 Tubulin_C
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
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Curation and family details
This family is new in this Pfam release.
|Number in seed:||18|
|Number in full:||276|
|Average length of the domain:||185.30 aa|
|Average identity of full alignment:||29 %|
|Average coverage of the sequence by the domain:||35.18 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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