Summary: Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal
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Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Provide feedback
This is the N-terminal region of the E or R chain, Ubiquitinol-cytochrome C reductase Fe-S subunit, of the hetero-hexameric cytochrome bc1 complex. This region is a TAT-signal region. The cytochrome bc1 complex is an oligomeric membrane protein complex that is a component of respiratory and photosynthetic electron transfer chains. The enzyme couples the transfer of electrons from ubiquinol to cytochrome c with the the generation of a protein gradient across the membrane . The motif is also associated with Rieske (PF00355), UCR_TM (PF02921) and Ubiq-Cytc-red_N (PF09165).
Hunte C, Koepke J, Lange C, Rossmanith T, Michel H; , Structure. 2000;8:669-684.: Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment. PUBMED:10873857 EPMC:10873857
Internal database links
|Similarity to PfamA using HHSearch:||TAT_signal|
This tab holds annotation information from the InterPro database.
InterPro entry IPR019470
This entry represents the TAT-signal region found in the iron-sulphur subunit of Ubiquinol-cytochrome C reductase (also known as the cytochrome bc1 complex). This enzymex is an oligomeric membrane protein complex that is a component of respiratory and photosynthetic electron transfer chains. It couples the transfer of electrons from ubiquinol to cytochrome c with the generation of a protein gradient across the membrane [PUBMED:10873857]. This entry is associated with INTERPRO, INTERPRO and INTERPRO.
|Molecular function||ubiquinol-cytochrome-c reductase activity (GO:0008121)|
|Biological process||oxidation-reduction process (GO:0055114)|
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This motif is found in a wide range of secreted proteins. It is named after the conserved pair of arginines that is followed by a hydrophobic stretch.
The clan contains the following 4 members:CytB6-F_Fe-S TAT_signal UCR_Fe-S_N UCR_TM
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Gene3D, pdb_1zrt|
|Author:||Finn RD, Coggill PC, Bateman A|
|Number in seed:||38|
|Number in full:||1117|
|Average length of the domain:||39.60 aa|
|Average identity of full alignment:||38 %|
|Average coverage of the sequence by the domain:||20.61 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the UCR_Fe-S_N domain has been found. There are 34 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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