Summary: Uncharacterized protein family UPF0016
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Uncharacterized protein family UPF0016 Provide feedback
This family contains integral membrane proteins of unknown function. Most members of the family contain two copies of a region that contains an EXGD motif. Each of these regions contains three predicted transmembrane regions.
Internal database links
|SCOOP:||TauE COX8 Mntp BacA PaRep2a OFeT_1|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR001727
A number of uncharacterised proteins share regions of similarities. These include,
- Saccharomyces cerevisiae (Baker's yeast) hypothetical protein YBR187w.
- Schizosaccharomyces pombe (Fission yeast) hypothetical protein SpAC17G8.08c.
- Mus musculus (Mouse) protein pFT27.
- Synechocystis sp. (strain PCC 6803) hypothetical protein sll0615.
These are hydrophobic proteins of 200 to 320 amino acids that seem to contain six or seven transmembrane domains.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||membrane (GO:0016020)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
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This clan includes a diverse range of transporter families .
The clan contains the following 17 members:BacA Cad Colicin_V DsbD DsbD_2 DUF475 HupE_UreJ HupE_UreJ_2 LysE MarC Mntp NicO OFeT_1 SfLAP TauE TerC UPF0016
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
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- an HTML-based viewer that uses DAS to retrieve alignment fragments on request
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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Curation and family details
|Author:||Finn RD, Bateman A|
|Number in seed:||765|
|Number in full:||10232|
|Average length of the domain:||75.10 aa|
|Average identity of full alignment:||34 %|
|Average coverage of the sequence by the domain:||58.65 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||15|
|Download:||download the raw HMM for this family|
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