Summary: Ureide permease
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Heterocyclic nitrogen compounds may serve as nitrogen sources or nitrogen transport compounds in plants that are not able to fix nitrogen. This family represents ureide permease, a transporter of a wide spectrum of oxo derivatives of heterocyclic nitrogen compounds, including allantoin, uric acid and xanthine; it has 10 putative transmembrane domains with a large cytosolic central domain containing a 'Walker A' motif. Ureide permease is likely to transport other purine degradation products when nitrogen sources are low. Transport is dependent on glucose and a proton gradient . The family is found in bacteria, plants and yeast.
Desimone M, Catoni E, Ludewig U, Hilpert M, Schneider A, Kunze R, Tegeder M, Frommer WB, Schumacher K;, Plant Cell. 2002;14:847-856.: A novel superfamily of transporters for allantoin and other oxo derivatives of nitrogen heterocyclic compounds in Arabidopsis. PUBMED:11971139 EPMC:11971139
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR009834
This entry represents ureide permease, which transports a wide spectrum of oxo derivatives of heterocyclic nitrogen compounds, including allantoin, uric acid and xanthine, but not adenine. Transport is dependent on glucose and a proton gradient [PUBMED:11971139].
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This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
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This clan contains a variety of transporters which have 4, 5, 9 or 10 membrane spanning helices. Many of the 10 membrane spanning transporters appear to be a duplication of the 5 spanning unit . Many of these families contain a characteristic glycine rich motif close to the C-terminus.
The clan contains the following 20 members:Cation_efflux CRCB CRT-like DUF1632 DUF486 DUF606 DUF914 EamA EmrE Mg_trans_NIPA Multi_Drug_Res Nuc_sug_transp RhaT Sugar_transport TPT UAA UPF0060 UPF0546 Ureide_permease Zip
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_11634 (release 10.0)|
|Previous IDs:||FAE_3-kCoA_syn1; Ureide_perm;|
|Author:||Vella Briffa B|
|Number in seed:||4|
|Number in full:||165|
|Average length of the domain:||229.70 aa|
|Average identity of full alignment:||39 %|
|Average coverage of the sequence by the domain:||66.75 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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