Summary: Vesicle transport v-SNARE protein N-terminus
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Vesicle transport v-SNARE protein N-terminus Provide feedback
V-SNARE proteins are required for protein traffic between eukaryotic organelles. The v-SNAREs on transport vesicles interact with t-SNAREs on target membranes in order to facilitate this . This domain is the N-terminal half of the V-Snare proteins.
Fischer von Mollard G, Stevens TH; , Mol Biol Cell 1999;10:1719-1732.: The Saccharomyces cerevisiae v-SNARE Vti1p is required for multiple membrane transport pathways to the vacuole. PUBMED:10359592 EPMC:10359592
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR007705
V-SNARE proteins are required for protein traffic between eukaryotic organelles. The v-SNAREs on transport vesicles interact with t-SNAREs on target membranes in order to facilitate this [PUBMED:10359592]. This domain is the N-terminal half of the V-Snare proteins.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||membrane (GO:0016020)|
|Biological process||intracellular protein transport (GO:0006886)|
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The members of this clan are involved in protein trafficking. The Sec20 family are integral membrane proteins involved in ER to Golgi transport  and V-SNARES are involved in membrane fusion .
The clan contains the following 3 members:Sec20 V-SNARE V-SNARE_C
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Curation and family details
|Seed source:||Pfam-B_5492 (release 7.6)|
|Number in seed:||89|
|Number in full:||491|
|Average length of the domain:||77.00 aa|
|Average identity of full alignment:||26 %|
|Average coverage of the sequence by the domain:||28.67 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the V-SNARE domain has been found. There are 5 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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