Summary: Viral D10 N-terminal
Viral D10 N-terminal Provide feedback
This domain is found on the N-terminus of the viral protein D10 (VD10) and the related MutT motif proteins . The VD10 protein is probably essential for virus replication  and is often found to the N-terminus of a PF00293 domain.
Binns MM, Britton BS, Mason C, Boursnell ME; , J Gen Virol 1990;71:2873-2881.: Analysis of the fowlpox virus genome region corresponding to the vaccinia virus D6 to A1 region: location of, and variation in, non-essential genes in poxviruses. PUBMED:2177083 EPMC:2177083
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This tab holds annotation information from the InterPro database.
InterPro entry IPR013683
This domain is found on the N terminus of the viral protein D10 (VD10) and the related MutT motif proteins [PUBMED:9847390]. The VD10 protein is probably essential for virus replication [PUBMED:2177083] and is often found to the N terminus of a NUDIX hydrolase domain.
Previous studies indicated that the vaccinia virus D10 protein, which is conserved in all sequenced poxviruses, participates in the rapid turnover of host and viral mRNAs. D10 contains a motif present in the family of Nudix/MutT enzymes, a subset of which has been shown to enhance mRNA turnover in eukaryotic cells through cleavage of the 5' cap (m7GpppNm-). The D10 protein possesses an intrinsic activity that liberates m7GDP from capped RNA substrates. Furthermore, point mutations in the Nudix/MutT motif abolished decapping activity. D10 has a strong affinity for capped RNA substrates of lengths of 24-309 nt were decapped efficiently. The poxviruses represent the only virus family shown to encode a Nudix hydrolase-decapping enzyme. The activity of the decapping and capping enzymes, accelerate mRNA turnover and helps to eliminate competing host mRNAs allowing stage-specific synthesis of viral proteins [PUBMED:17283339].
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|Molecular function||phosphatase activity (GO:0016791)|
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Curation and family details
|Seed source:||Pfam-B_4155 (release 18.0)|
|Number in seed:||7|
|Number in full:||51|
|Average length of the domain:||44.80 aa|
|Average identity of full alignment:||58 %|
|Average coverage of the sequence by the domain:||18.60 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
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