Summary: von Willebrand factor type C domain
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Von Willebrand factor type C domain Edit Wikipedia article
|von Willebrand factor type C domain|
Von Willebrand factor, type C (VWFC or VWC)is a protein domain is found in various blood plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular proteins.
Although the majority of VWA-containing proteins are extracellular, the most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport and the proteasome.
A common feature appears to be involvement in multiprotein complexes. Proteins that incorporate vWF domains participate in numerous biological events (e.g. cell adhesion, migration, homing, pattern formation, and signal transduction), involving interaction with a large array of ligands.
A number of human diseases arise from mutations in VWA domains.
The domain is named after the von Willebrand factor (VWF) type C repeat which is found in multidomain protein/multifunctional proteins involved in maintaining homeostasis. For the von Willebrand factor the duplicated VWFC domain is thought to participate in oligomerization, but not in the initial dimerization step. The presence of this region in a number of other complex-forming proteins points to the possible involvement of the VWFC domain in complex formation.
Human proteins containing this domain
- BMP binding endothelial regulator (BMPER)
- Cysteine-rich motor neuron 1 protein (CRIM1)
- Extracellular matrix protein 2 (ECM2)
- Fraser extracellular matrix complex subunit 1 (FRAS1)
- Neural EGFL like 1 (NELL1)
- Neural EGFL like 2 (NELL2)
- Peroxidasin like (PXDNL)
- Von Willebrand factor C and EGF domain-containing protein (VWCE)
- Von Willebrand factor (VWF)
- Collagen, type I, alpha 1 (COL1A1)
- Collagen, type II, alpha 1 (COL2A1)
- Collagen, type III, alpha 1 (COL3A1)
- Collagen, type V, alpha 2 (COL5A2)
- CCN1: Cysteine-rich angiogenic inducer 61 (CYR61)
- CCN2: Connective tissue growth factor (CTGF)
- CCN3: Nephroblastoma overexpressed (NOV)
- CCN4: WNT1-inducible-signaling pathway protein 1 (WISP1)
- CCN5: WNT1-inducible-signaling pathway protein 2 (WISP2)
- Colombatti A, Bonaldo P, Doliana R (1993). "Type A modules: interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins". Matrix 13 (4): 297–306. doi:10.1016/S0934-8832(11)80025-9. PMID 8412987.
- Smith KF, Haris PI, Chapman D, Perkins SJ, Williams SC, Sim RB (1994). "The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform infrared spectroscopy. Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. Mol. Biol. 238 (1): 104–119. doi:10.1006/jmbi.1994.1271. PMID 8145250.
- Bork P (1991). "Shuffled domains in extracellular proteins". FEBS Lett. 286 (1): 47–54. doi:10.1016/0014-5793(91)80937-X. PMID 1864378.
- Hunt LT, Barker WC (1987). "von Willebrand factor shares a distinctive cysteine-rich domain with thrombospondin and procollagen". Biochem. Biophys. Res. Commun. 144 (2): 876–882. doi:10.1016/S0006-291X(87)80046-3. PMID 3495268.
- Voorberg J, Fontijn R, Calafat J, Janssen H, van Mourik JA, Pannekoek H (1991). "Assembly and routing of von Willebrand factor variants: the requirements for disulfide-linked dimerization reside within the carboxy-terminal 151 amino acids". J. Cell Biol. 113 (1): 195–205. doi:10.1083/jcb.113.1.195. PMC 2288914. PMID 2007623.
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The high cutoff was used to prevent overlap with PF00094.
Internal database links
|SCOOP:||Pacifastin_I PSP94 CFC TILa Amnionless|
|Similarity to PfamA using HHSearch:||TILa|
This tab holds annotation information from the InterPro database.
InterPro entry IPR001007The vWF domain is found in various plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular proteins [PUBMED:8412987, PUBMED:8145250, PUBMED:1864378]. Although the majority of VWA-containing proteins are extracellular, the most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport and the proteasome. A common feature appears to be involvement in multiprotein complexes. Proteins that incorporate vWF domains participate in numerous biological events (e.g. cell adhesion, migration, homing, pattern formation, and signal transduction), involving interaction with a large array of ligands [PUBMED:8412987]. A number of human diseases arise from mutations in VWA domains. Secondary structure prediction from 75 aligned vWF sequences has revealed a largely alternating sequence of alpha-helices and beta-strands [PUBMED:8145250]. The domain is named after the von Willebrand factor (VWF) type C repeat which is found in multidomain protein/multifunctional proteins involved in maintaining homeostasis [PUBMED:3495268, PUBMED:1864378]. For the von Willebrand factor the duplicated VWFC domain is thought to participate in oligomerization, but not in the initial dimerization step [PUBMED:2007623]. The presence of this region in a number of other complex-forming proteins points to the possible involvment of the VWFC domain in complex formation.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||protein binding (GO:0005515)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
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This superfamily is characterised by being disulfide-rich, all-beta with an extra C-terminal domain in the fibronectin-like, Fn1, members.
The clan contains the following 5 members:fn1 Pacifastin_I PSP94 TILa VWC
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the UniProtKB sequence database using the family HMM
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
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Curation and family details
|Number in seed:||19|
|Number in full:||4263|
|Average length of the domain:||58.70 aa|
|Average identity of full alignment:||33 %|
|Average coverage of the sequence by the domain:||12.15 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||15|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the VWC domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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