Summary: Viral coat protein (S domain)
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Viral coat protein (S domain) Provide feedback
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This tab holds annotation information from the InterPro database.
InterPro entry IPR000937The capsid proteins of plant icosahedral positive strand RNA viruses form 4 different domains, a positively charged, N-terminal 'R' domain, which interacts with RNA (66 residues); a connecting arm, 'a' (35 residues); a central, surface 'S' domain, which forms the virion shell; and a projecting, C-terminal `P' domain [PUBMED:7704529]. Some of the viruses lack either the R or P domains. The S domain contains from 158 to 166 amino acids and comprises 8 anti-parallel beta-strands, which form a twisted sheet or jelly-roll fold. This structure is shared by a number of plant viral capsid proteins, which include: Carmovirus, Dianthovirus, Sobemovirus, Tombusvirus and an unidentified tobacco necrosis virus [PUBMED:1856686].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||viral capsid (GO:0019028)|
|Molecular function||structural molecule activity (GO:0005198)|
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The clan contains a set of viral coat protein families and peptidase A6. The only known peptidase activity is an autolytic cleavage releasing a 44-residue C-terminal fragment. The reaction is very slow and only occurs within the assembled virion. There is debate whether this is actually a true peptidase. The virion with these coat or capsid proteins are icosahedral viruses containing sixty triangular coat protein units, each unit consisting of three proteins. The coat protein consists of two subdomains, an eight-stranded beta-barrel on the surface and a three-helix bundle on the inner face.
The clan contains the following 26 members:Astro_capsid_N Birna_VP2 Bromo_coat Calici_coat Calici_coat_C Capsid-VNN Carmo_coat_C Circo_capsid Como_LCP Como_SCP CRPV_capsid Cucumo_coat Dicistro_VP4 Luteo_coat Nepo_coat Nepo_coat_C Nepo_coat_N Peptidase_A21 Peptidase_A6 Pico_P1A Rhv SP2 TT_ORF1 Tymo_coat Viral_coat VP4_2
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_870 (release 2.1)|
|Author:||Bateman A, Griffiths-Jones SR|
|Number in seed:||10|
|Number in full:||14|
|Average length of the domain:||200.90 aa|
|Average identity of full alignment:||24 %|
|Average coverage of the sequence by the domain:||63.61 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||15|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Viral_coat domain has been found. There are 424 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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