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Vps51/Vps67 Provide feedback
This family includes a presumed domain found in a number of components of vesicular transport. The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved recycling of proteins from endosomes to the late Golgi . Vps51 (also known as Vps67) is a subunit of VFT and interacts with the SNARE Tlg1 . Cog1_N is the N-terminus of the Cog1 subunit of the eight-unit Conserved Oligomeric Golgi (COG) complex that participates in retrograde vesicular transport and is required to maintain normal Golgi structure and function. The subunits are located in two lobes and Cog1 serves to bind the two lobes together probably via the highly conserved N-terminal domain of approximately 85 residues .
Fotso P, Koryakina Y, Pavliv O, Tsiomenko AB, Lupashin VV; , J Biol Chem. 2005;280:27613-27623.: Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex. PUBMED:15932880 EPMC:15932880
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR014812
The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved in recycling of proteins from endosomes to the late Golgi. Vps51 (also known as Vps67) is a subunit of VFT and interacts with the SNARE Tlg1 [PUBMED:12377769].
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This clan includes an N-terminal domain from several vesicle transport proteins that are related to Vps51.
The clan contains the following 16 members:COG2 COG5 COG6 Dor1 DUF2450 Exo70 Sec15 Sec3_C Sec3_C_2 Sec5 Sec6 Sec8_exocyst Vps51 Vps52 Vps53_N Zw10
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Curation and family details
|Author:||Mistry J, Wood V|
|Number in seed:||56|
|Number in full:||831|
|Average length of the domain:||83.80 aa|
|Average identity of full alignment:||20 %|
|Average coverage of the sequence by the domain:||11.90 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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