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0  structures 212  species 0  interactions 272  sequences 9  architectures

Family: Wbp11 (PF09429)

Summary: WW domain binding protein 11

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WBP11 Edit Wikipedia article

Wbp11
Identifiers
Symbol Wbp11
Pfam PF09429
InterPro IPR019007
WW domain binding protein 11
Identifiers
Symbols WBP11 ; NPWBP; PPP1R165; SIPP1; WBP-11
External IDs MGI1891823 HomoloGene134037 GeneCards: WBP11 Gene
Orthologs
Species Human Mouse
Entrez 51729 60321
Ensembl ENSG00000084463 ENSMUSG00000030216
UniProt Q9Y2W2 Q923D5
RefSeq (mRNA) NM_016312 NM_021714
RefSeq (protein) NP_057396 NP_068360
Location (UCSC) Chr 12:
14.94 – 14.96 Mb
Chr 6:
136.81 – 136.83 Mb
PubMed search [1] [2]

Alternative Names

  • WW domain binding protein 11 (WBP1)
  • Rsp5
  • WWP domain

Function

WW domain-binding protein 11 is a protein that in humans, is encoded by the WBP11 gene. The function of WBP11 is to play a role in the regulation of pre-mRNA processing. More specifically, this nuclear protein, colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks.[1][2]

Structure

The WW domain is a short conserved region in a number of unrelated proteins, which folds as a stable, triple stranded beta-sheet. This short domain of approximately 40 amino acids, may be repeated up to four times in some proteins.[3][4][5][6] The name WW or WWP derives from the presence of two signature tryptophan residues that are spaced 20-23 amino acids apart and are present in most WW domains known to date, as well as that of a conserved Proline. The WW domain binds to proteins with particular proline-motifs, [AP]-P-P-[AP]-Y, and/or phosphoserine- phosphothreonine-containing motifs.[7][8] It is frequently associated with other domains typical for proteins in signal transduction processes.

Protein interactions

Wbp11 contains two proline-rich regions that bind to the WW domain of the nuclear protein, Npw38, hence leading to its alternative name, Npw38-binding protein, NpwBP. The Npw38-NpwBP complex functions as a component of an mRNA factory in the nucleus.[2] WBP11 has also been shown to interact with PQBP1.[1][9]

Proteins containing Wbp11 domain

A large variety of proteins containing the WW domain are known. These include:

References

  1. ^ a b Komuro A, Saeki M, Kato S (January 2000). "Association of two nuclear proteins, Npw38 and NpwBP, via the interaction between the WW domain and a novel proline-rich motif containing glycine and arginine". J Biol Chem 274 (51): 36513–9. doi:10.1074/jbc.274.51.36513. PMID 10593949. 
  2. ^ a b "Entrez Gene: WBP11 WW domain binding protein 11". 
  3. ^ Bork P, Sudol M (December 1994). "The WW domain: a signalling site in dystrophin?". Trends Biochem. Sci. 19 (12): 531–3. doi:10.1016/0968-0004(94)90053-1. PMID 7846762. 
  4. ^ André B, Springael JY (December 1994). "WWP, a new amino acid motif present in single or multiple copies in various proteins including dystrophin and the SH3-binding Yes-associated protein YAP65". Biochem. Biophys. Res. Commun. 205 (2): 1201–5. doi:10.1006/bbrc.1994.2793. PMID 7802651. 
  5. ^ Hofmann K, Bucher P (January 1995). "The rsp5-domain is shared by proteins of diverse functions". FEBS Lett. 358 (2): 153–7. doi:10.1016/0014-5793(94)01415-W. PMID 7828727. 
  6. ^ Sudol M, Chen HI, Bougeret C, Einbond A, Bork P (August 1995). "Characterization of a novel protein-binding module--the WW domain". FEBS Lett. 369 (1): 67–71. doi:10.1016/0014-5793(95)00550-S. PMID 7641887. 
  7. ^ Chen HI, Sudol M (August 1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7819–23. doi:10.1073/pnas.92.17.7819. PMC 41237. PMID 7644498. 
  8. ^ Macias MJ, Wiesner S, Sudol M (February 2002). "WW and SH3 domains, two different scaffolds to recognize proline-rich ligands". FEBS Lett. 513 (1): 30–7. doi:10.1016/S0014-5793(01)03290-2. PMID 11911877. 
  9. ^ Zhang, Y; Lindblom T; Chang A; Sudol M; Sluder A E; Golemis E A (October 2000). "Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1". Gene (NETHERLANDS) 257 (1): 33–43. doi:10.1016/S0378-1119(00)00372-3. ISSN 0378-1119. PMID 11054566. 

This article incorporates text from the public domain Pfam and InterPro IPR019007

Further reading


This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

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WW domain binding protein 11 Provide feedback

The WW domain is a small protein module with a triple-stranded beta-sheet fold. This is a family of WW domain binding proteins.

Literature references

  1. Komuro A, Saeki M, Kato S;, J Biol Chem. 1999;274:36513-36519.: Association of two nuclear proteins, Npw38 and NpwBP, via the interaction between the WW domain and a novel proline-rich motif containing glycine and arginine. PUBMED:10593949 EPMC:10593949


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR019007

Synonym(s): Rsp5 or WWP domain

The WW domain is a short conserved region in a number of unrelated proteins, which folds as a stable, triple stranded beta-sheet. This short domain of approximately 40 amino acids, may be repeated up to four times in some proteins [PUBMED:7846762, PUBMED:7802651, PUBMED:7828727, PUBMED:7641887]. The name WW or WWP derives from the presence of two signature tryptophan residues that are spaced 20-23 amino acids apart and are present in most WW domains known to date, as well as that of a conserved Pro. The WW domain binds to proteins with particular proline-motifs, [AP]-P-P-[AP]-Y, and/or phosphoserine- phosphothreonine-containing motifs [PUBMED:7644498, PUBMED:11911877]. It is frequently associated with other domains typical for proteins in signal transduction processes.

A large variety of proteins containing the WW domain are known. These include; dystrophin, a multidomain cytoskeletal protein; utrophin, a dystrophin-like protein of unknown function; vertebrate YAP protein, substrate of an unknown serine kinase; Mus musculus (Mouse) NEDD-4, involved in the embryonic development and differentiation of the central nervous system; Saccharomyces cerevisiae (Baker's yeast) RSP5, similar to NEDD-4 in its molecular organisation; Rattus norvegicus (Rat) FE65, a transcription-factor activator expressed preferentially in liver; Nicotiana tabacum (Common tobacco) DB10 protein, amongst others.

This entry represents WW domain-binding protein 11, which may play a role in the regulation of pre-mRNA processing.

Gene Ontology

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Domain organisation

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Alignments

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Full
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Representative proteomes NCBI
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RP35
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  Seed
(30)
Full
(272)
Representative proteomes NCBI
(259)
Meta
(1)
RP15
(63)
RP35
(99)
RP55
(149)
RP75
(198)
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  Seed
(30)
Full
(272)
Representative proteomes NCBI
(259)
Meta
(1)
RP15
(63)
RP35
(99)
RP55
(149)
RP75
(198)
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External links

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Curation and family details

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Seed source: Pfam-B_13108 (release 21.0)
Previous IDs: none
Type: Family
Author: Mistry J, Wood V
Number in seed: 30
Number in full: 272
Average length of the domain: 77.90 aa
Average identity of full alignment: 41 %
Average coverage of the sequence by the domain: 17.48 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.1 21.1
Trusted cut-off 21.7 21.7
Noise cut-off 20.7 20.7
Model length: 78
Family (HMM) version: 5
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