Summary: Yip1 domain
Yip1 domain Provide feedback
The Yip1 integral membrane domain contains four transmembrane alpha helices. The domain is characterised by the motifs DLYGP and GY. The Yip1 protein is a golgi protein involved in vesicular transport that interacts with GTPases .
Yang X, Matern HT, Gallwitz D; , EMBO J 1998;17:4954-4963.: Specific binding to a novel and essential Golgi membrane protein (Yip1p) functionally links the transport GTPases Ypt1p and Ypt31p. PUBMED:9724632 EPMC:9724632
Internal database links
|SCOOP:||DUF1189 DUF1282 YIF1|
|Similarity to PfamA using HHSearch:||DUF1282|
This tab holds annotation information from the InterPro database.
InterPro entry IPR006977
This entry contains proteins belonging to the Yip1 family and represents the Yip1 domain. The Yip1 integral membrane domain contains four transmembrane alpha helices. The domain is characterised by the motifs DLYGP and GY. The Yip1 protein is a golgi protein involved in vesicular transport that interacts with GTPases [PUBMED:9724632].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||membrane (GO:0016020)|
- the number of sequences which exhibit this architecture
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This example describes an architecture with one
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- the UniProt description of the protein sequence
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Yip1 and YIF1 are members of an integral membrane complex which bind to Ras-like GTPases and are required for membrane fusion of ER derived vesicles with the Golgi .
The clan contains the following 6 members:DUF1048 DUF1129 DUF1282 DUF1700 YIF1 Yip1
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the UniProtKB sequence database using the family HMM
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
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Curation and family details
|Seed source:||Pfam-B_5598 (release 7.6)|
|Author:||Finn RD, Bateman A|
|Number in seed:||206|
|Number in full:||3302|
|Average length of the domain:||173.00 aa|
|Average identity of full alignment:||15 %|
|Average coverage of the sequence by the domain:||62.36 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||16|
|Download:||download the raw HMM for this family|
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