Summary: ZIP Zinc transporter
ZIP Zinc transporter Provide feedback
The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant . Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.
Grotz N, Fox T, Connolly E, Park W, Guerinot ML, Eide D; , Proc Natl Acad Sci U S A 1998;95:7220-7224.: Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency. PUBMED:9618566 EPMC:9618566
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR003689These ZIP zinc transporter proteins define a family of metal ion transporters that are found in plants, protozoa, fungi, invertebrates, and vertebrates, making it now possible to address questions of metal ion accumulation and homeostasis in diverse organisms [PUBMED:9618566].
|Cellular component||membrane (GO:0016020)|
|Molecular function||metal ion transmembrane transporter activity (GO:0046873)|
|Biological process||transmembrane transport (GO:0055085)|
|metal ion transport (GO:0030001)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
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This clan contains a variety of transporters which have 4, 5, 9 or 10 membrane spanning helices. Many of the 10 membrane spanning transporters appear to be a duplication of the 5 spanning unit . Many of these families contain a characteristic glycine rich motif close to the C-terminus.
The clan contains the following 20 members:Cation_efflux CRCB CRT-like DUF1632 DUF486 DUF606 DUF914 EamA EmrE Mg_trans_NIPA Multi_Drug_Res Nuc_sug_transp RhaT Sugar_transport TPT UAA UPF0060 UPF0546 Ureide_permease Zip
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
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Curation and family details
|Seed source:||Pfam-B_1189 (release 5.4) & Pfam-B_1903 (Release 7.5)|
|Author:||Bashton M, Bateman A|
|Number in seed:||40|
|Number in full:||6416|
|Average length of the domain:||223.60 aa|
|Average identity of full alignment:||18 %|
|Average coverage of the sequence by the domain:||74.42 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||17|
|Download:||download the raw HMM for this family|
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