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761  structures 4127  species 0  interactions 31610  sequences 322  architectures

Family: peroxidase (PF00141)

Summary: Peroxidase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Haem peroxidase". More...

Haem peroxidase Edit Wikipedia article

Peroxidase
Identifiers
Symbolperoxidase
PfamPF00141
InterProIPR002016
PROSITEPDOC00394
SCOPe1hsr / SUPFAM
CDDcd00314
Fungal peroxidase extension region
Identifiers
SymbolPeroxidase_ext
PfamPF11895
InterProIPR024589

Haem peroxidases (or heme peroxidases) are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyse a number of oxidative reactions. Most haem peroxidases follow the reaction scheme:

Fe3+ + H2O2 [Fe4+=O]R' (Compound I) + H2O
[Fe4+=O]R' + substrate --> [Fe4+=O]R (Compound II) + oxidized substrate
[Fe4+=O]R + substrate --> Fe3+ + H2O + oxidized substrate

In this mechanism, the enzyme reacts with one equivalent of H2O2 to give [Fe4+=O]R' (compound I). This is a two-electron oxidation/reduction reaction in which H2O2 is reduced to water and the enzyme is oxidized. One oxidizing equivalent resides on iron, giving the oxyferryl[1] intermediate, and in many peroxidases the porphyrin (R) is oxidized to the porphyrin pi-cation radical (R'). Compound I then oxidizes an organic substrate to give a substrate radical[2] and Compound II, which can then oxidize a second substrate molecule.

Haem peroxidases include two superfamilies: one found in bacteria, fungi, and plants, and the second found in animals. The first one can be viewed as consisting of 3 major classes:[3]

  • Class I, the intracellular peroxidases, includes: yeast cytochrome c peroxidase (CCP), a soluble protein found in the mitochondrial electron transport chain, where it probably protects against toxic peroxides; ascorbate peroxidase (AP), the main enzyme responsible for hydrogen peroxide removal in chloroplasts and cytosol of higher plants;[4] and bacterial catalase- peroxidases, exhibiting both peroxidase and catalase activities. It is thought that catalase-peroxidase provides protection to cells under oxidative stress.[5]
  • Class II consists of secretory fungal peroxidases: ligninases, or lignin peroxidases (LiPs), and manganese-dependent peroxidases (MnPs). These are monomeric glycoproteins involved in the degradation of lignin. In MnP, Mn2+ serves as the reducing substrate.[6] Class II proteins contain four conserved disulphide bridges and two conserved calcium-binding sites.
  • Class III consists of the secretory plant peroxidases, which have multiple tissue-specific functions: e.g., removal of hydrogen peroxide from chloroplasts and cytosol; oxidation of toxic compounds; biosynthesis of the cell wall; defence responses towards wounding; indole-3-acetic acid (IAA) catabolism; ethylene biosynthesis; and so on.[7] Class III proteins are also monomeric glycoproteins, containing four conserved disulphide bridges and two calcium ions, although the placement of the disulphides differs from class II enzymes.

The crystal structures of a number of these proteins show that they share the same architecture - two all-alpha domains between which the haem group is embedded.

Another family of haem peroxidases is the DyP-type peroxidase family.[8]

References

  1. ^ Nelson RE, Fessler LI, Takagi Y, Blumberg B, Keene DR, Olson PF, Parker CG, Fessler JH (1994). "Peroxidasin: a novel enzyme-matrix protein of Drosophila development". EMBO J. 13 (15): 3438–3447. PMC 395246. PMID 8062820.
  2. ^ Poulos TL, Li H (1994). "Structural variation in heme enzymes: a comparative analysis of peroxidase and P450 crystal structures". Structure. 2 (6): 461–464. doi:10.1016/S0969-2126(00)00046-0. PMID 7922023.
  3. ^ Welinder KG (1992). "Superfamily of plant, fungal and bacterial peroxidases". Curr. Opin. Struct. Biol. 2 (3): 388–393. doi:10.1016/0959-440X(92)90230-5.
  4. ^ Dalton DA (1991). "Ascorbate peroxidase". 2: 139–153. Cite journal requires |journal= (help)
  5. ^ Welinder KG (1991). "Bacterial catalase-peroxidases are gene duplicated members of the plant peroxidase superfamily". Biochim. Biophys. Acta. 1080 (3): 215–220. doi:10.1016/0167-4838(91)90004-j. PMID 1954228.
  6. ^ Reddy CA, D Souza TM (1994). "Physiology and molecular biology of the lignin peroxidases of Phanerochaete chrysosporium". FEMS Microbiol. Rev. 13 (2): 137–152. doi:10.1111/j.1574-6976.1994.tb00040.x. PMID 8167033.
  7. ^ Campa A (1991). "Biological roles of plant peroxidases: known and potential function". 2: 25–50. Cite journal requires |journal= (help)
  8. ^ Zubieta C, Krishna SS, Kapoor M, Kozbial P, McMullan D, Axelrod HL, Miller MD, Abdubek P, Ambing E, Astakhova T, Carlton D, Chiu HJ, Clayton T, Deller MC, Duan L, Elsliger MA, Feuerhelm J, Grzechnik SK, Hale J, Hampton E, Han GW, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kumar A, Marciano D, Morse AT, Nigoghossian E, Okach L, Oommachen S, Reyes R, Rife CL, Schimmel P, van den Bedem H, Weekes D, White A, Xu Q, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA (November 2007). "Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif". Proteins. 69 (2): 223–33. doi:10.1002/prot.21550. PMID 17654545.
This article incorporates text from the public domain Pfam and InterPro: IPR002016

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Peroxidase Provide feedback

No Pfam abstract.

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002016

This entry represents the first type of haem peroxidases found in bacteria, fungi, plants.

Peroxidases are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyse a number of oxidative reactions. Most haem peroxidases follow the reaction scheme: Fe 3+ + H 2 O 2 --> [Fe 4+ =O]R' (Compound I) + H 2 O [Fe 4+ =O]R' + substrate --> [Fe 4+ =O]R (Compound II) + oxidised substrate [Fe 4+ =O]R + substrate --> Fe 3+ + H 2 O + oxidised substrate

In this mechanism, the enzyme reacts with one equivalent of H 2 O 2 to give [Fe 4+ =O]R' (compound I). This is a two-electron oxidation/reduction reaction where H 2 O 2 is reduced to water and the enzyme is oxidised. One oxidising equivalent resides on iron, giving the oxyferryl [ PUBMED:8062820 ] intermediate, while in many peroxidases the porphyrin (R) is oxidised to the porphyrin pi-cation radical (R'). Compound I then oxidises an organic substrate to give a substrate radical [ PUBMED:7922023 ].

Haem peroxidases include two superfamilies: one found in bacteria, fungi, plants and the second found in animals. The first one can be viewed as consisting of 3 major classes. Class I, the intracellular peroxidases, includes: yeast cytochrome c peroxidase (CCP), a soluble protein found in the mitochondrial electron transport chain, where it probably protects against toxic peroxides; ascorbate peroxidase (AP), the main enzyme responsible for hydrogen peroxide removal in chloroplasts and cytosol of higher plants; and bacterial catalase- peroxidases, exhibiting both peroxidase and catalase activities. It is thought that catalase-peroxidase provides protection to cells under oxidative stress [ PUBMED:1954228 ].

Class II consists of secretory fungal peroxidases: ligninases, or lignin peroxidases (LiPs), and manganese-dependent peroxidases (MnPs). These are monomeric glycoproteins involved in the degradation of lignin. In MnP, Mn 2+ serves as the reducing substrate [ PUBMED:8167033 ]. Class II proteins contain four conserved disulphide bridges and two conserved calcium-binding sites.

Class III consists of the secretory plant peroxidases, which have multiple tissue-specific functions: e.g., removal of hydrogen peroxide from chloroplasts and cytosol; oxidation of toxic compounds; biosynthesis of the cell wall; defence responses towards wounding; indole-3-acetic acid (IAA) catabolism; ethylene biosynthesis; and so on. Class III proteins are also monomeric glycoproteins, containing four conserved disulphide bridges and two calcium ions, although the placement of the disulphides differs from class II enzymes.

The crystal structures of a number of these proteins show that they share the same architecture - two all-alpha domains between which the haem group is embedded.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Peroxidase (CL0617), which has the following description:

This superfamily includes two families of heme-dependent peroxidases that have an all alpha helical fold.

The clan contains the following 3 members:

An_peroxidase peroxidase Peroxidase_ext

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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(156)
Full
(31610)
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(76092)
RP15
(3498)
RP35
(15531)
RP55
(27178)
RP75
(39860)
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  Seed
(156)
Full
(31610)
Representative proteomes UniProt
(76092)
RP15
(3498)
RP35
(15531)
RP55
(27178)
RP75
(39860)
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  Seed
(156)
Full
(31610)
Representative proteomes UniProt
(76092)
RP15
(3498)
RP35
(15531)
RP55
(27178)
RP75
(39860)
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

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HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite; PfamB-105, Release 14.0;
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A , Sonnhammer ELL , Studholme DJ
Number in seed: 156
Number in full: 31610
Average length of the domain: 242.70 aa
Average identity of full alignment: 25 %
Average coverage of the sequence by the domain: 73.43 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.2 20.2
Trusted cut-off 20.2 20.2
Noise cut-off 20.1 20.1
Model length: 229
Family (HMM) version: 25
Download: download the raw HMM for this family

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the peroxidase domain has been found. There are 761 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0N7KCT0 View 3D Structure Click here
A0A0N7KCT0 View 3D Structure Click here
A0A0N7KIG3 View 3D Structure Click here
A0A0N7KK39 View 3D Structure Click here
A0A0N7KP42 View 3D Structure Click here
A0A0N7KS49 View 3D Structure Click here
A0A0N7KST9 View 3D Structure Click here
A0A0P0UYV2 View 3D Structure Click here
A0A0P0V1F6 View 3D Structure Click here
A0A0P0V1F6 View 3D Structure Click here
A0A0P0V2A4 View 3D Structure Click here
A0A0P0V2C2 View 3D Structure Click here
A0A0P0V2S1 View 3D Structure Click here
A0A0P0VD47 View 3D Structure Click here
A0A0P0VV33 View 3D Structure Click here
A0A0P0VXU6 View 3D Structure Click here
A0A0P0VYD2 View 3D Structure Click here
A0A0P0VZ16 View 3D Structure Click here
A0A0P0W6E8 View 3D Structure Click here
A0A0P0WHP0 View 3D Structure Click here
A0A0P0WX52 View 3D Structure Click here
A0A0P0WX52 View 3D Structure Click here
A0A0P0WX92 View 3D Structure Click here
A0A0P0WXK0 View 3D Structure Click here
A0A0P0X1D6 View 3D Structure Click here
A0A0P0X2D3 View 3D Structure Click here
A0A0P0X2E2 View 3D Structure Click here
A0A0P0X9E4 View 3D Structure Click here
A0A0P0X9R7 View 3D Structure Click here
A0A0P0X9S3 View 3D Structure Click here
A0A0P0XHX9 View 3D Structure Click here
A0A0P0XS14 View 3D Structure Click here
A0A0P0Y871 View 3D Structure Click here
A0A0R0EQP6 View 3D Structure Click here
A0A0R0EQR9 View 3D Structure Click here
A0A0R0ERN0 View 3D Structure Click here
A0A0R0ERX9 View 3D Structure Click here
A0A0R0ESX9 View 3D Structure Click here
A0A0R0EVL7 View 3D Structure Click here
A0A0R0EVL7 View 3D Structure Click here
A0A0R0EX11 View 3D Structure Click here
A0A0R0F689 View 3D Structure Click here
A0A0R0FS01 View 3D Structure Click here
A0A0R0FTH1 View 3D Structure Click here
A0A0R0G0P1 View 3D Structure Click here
A0A0R0G9U6 View 3D Structure Click here
A0A0R0G9U6 View 3D Structure Click here
A0A0R0GAW6 View 3D Structure Click here
A0A0R0GAW6 View 3D Structure Click here
A0A0R0GAY5 View 3D Structure Click here
A0A0R0GE09 View 3D Structure Click here
A0A0R0GER2 View 3D Structure Click here
A0A0R0GIU4 View 3D Structure Click here
A0A0R0GK31 View 3D Structure Click here
A0A0R0GNN3 View 3D Structure Click here
A0A0R0GWL6 View 3D Structure Click here
A0A0R0GXD9 View 3D Structure Click here
A0A0R0H8T5 View 3D Structure Click here
A0A0R0HAI3 View 3D Structure Click here
A0A0R0HAI3 View 3D Structure Click here
A0A0R0HBY6 View 3D Structure Click here
A0A0R0HDJ7 View 3D Structure Click here
A0A0R0HGS5 View 3D Structure Click here
A0A0R0HJK0 View 3D Structure Click here
A0A0R0HJK0 View 3D Structure Click here
A0A0R0HLQ4 View 3D Structure Click here
A0A0R0HPI8 View 3D Structure Click here
A0A0R0HQJ0 View 3D Structure Click here
A0A0R0I1Y7 View 3D Structure Click here
A0A0R0I2M6 View 3D Structure Click here
A0A0R0I2R8 View 3D Structure Click here
A0A0R0IB84 View 3D Structure Click here
A0A0R0IB84 View 3D Structure Click here
A0A0R0INP8 View 3D Structure Click here
A0A0R0IU25 View 3D Structure Click here
A0A0R0J616 View 3D Structure Click here
A0A0R0JGK9 View 3D Structure Click here
A0A0R0JSG7 View 3D Structure Click here
A0A0R0JWJ9 View 3D Structure Click here
A0A0R0JYS9 View 3D Structure Click here
A0A0R0KI57 View 3D Structure Click here
A0A0R0KJA5 View 3D Structure Click here
A0A0R0KM06 View 3D Structure Click here
A0A0R0KQT7 View 3D Structure Click here
A0A0R0KSM2 View 3D Structure Click here
A0A0R0KZD9 View 3D Structure Click here
A0A0R0LCA3 View 3D Structure Click here
A0A0R0LEG7 View 3D Structure Click here
A0A0R4J2Q9 View 3D Structure Click here
A0A0R4J2T7 View 3D Structure Click here
A0A0R4J3J1 View 3D Structure Click here
A0A0R4J4C4 View 3D Structure Click here
A0A0R4J4T3 View 3D Structure Click here
A0A0R4J4U7 View 3D Structure Click here
A0A0R4J4W7 View 3D Structure Click here
A0A0R4J539 View 3D Structure Click here
A0A0R4J594 View 3D Structure Click here
A0A0R4J5A2 View 3D Structure Click here
A0A0R4J5E9 View 3D Structure Click here
A0A0R4J5J5 View 3D Structure Click here
A0A0R4J5N4 View 3D Structure Click here
A0A0R4J5X1 View 3D Structure Click here
A0A1D6DVY9 View 3D Structure Click here
A0A1D6E0N6 View 3D Structure Click here
A0A1D6E530 View 3D Structure Click here
A0A1D6E534 View 3D Structure Click here
A0A1D6E534 View 3D Structure Click here
A0A1D6E8Y9 View 3D Structure Click here
A0A1D6EB02 View 3D Structure Click here
A0A1D6ELH9 View 3D Structure Click here
A0A1D6ESJ9 View 3D Structure Click here
A0A1D6F256 View 3D Structure Click here
A0A1D6F265 View 3D Structure Click here
A0A1D6F4C8 View 3D Structure Click here
A0A1D6FBJ6 View 3D Structure Click here
A0A1D6FCM2 View 3D Structure Click here
A0A1D6FGJ9 View 3D Structure Click here
A0A1D6FHV4 View 3D Structure Click here
A0A1D6FP28 View 3D Structure Click here
A0A1D6FQT9 View 3D Structure Click here
A0A1D6FUY7 View 3D Structure Click here
A0A1D6FUY8 View 3D Structure Click here
A0A1D6GQ39 View 3D Structure Click here
A0A1D6GUF7 View 3D Structure Click here
A0A1D6GUF8 View 3D Structure Click here
A0A1D6GUF9 View 3D Structure Click here
A0A1D6GUG0 View 3D Structure Click here
A0A1D6H650 View 3D Structure Click here
A0A1D6H652 View 3D Structure Click here
A0A1D6H655 View 3D Structure Click here
A0A1D6H658 View 3D Structure Click here
A0A1D6H7N5 View 3D Structure Click here
A0A1D6HAE2 View 3D Structure Click here
A0A1D6HCQ0 View 3D Structure Click here
A0A1D6HJV5 View 3D Structure Click here
A0A1D6HQQ8 View 3D Structure Click here
A0A1D6HQQ8 View 3D Structure Click here
A0A1D6HQQ9 View 3D Structure Click here
A0A1D6HUY9 View 3D Structure Click here
A0A1D6HWB8 View 3D Structure Click here
A0A1D6HX87 View 3D Structure Click here
A0A1D6I695 View 3D Structure Click here
A0A1D6I6C2 View 3D Structure Click here
A0A1D6I6C2 View 3D Structure Click here
A0A1D6I839 View 3D Structure Click here
A0A1D6IBW1 View 3D Structure Click here
A0A1D6II57 View 3D Structure Click here
A0A1D6IKV7 View 3D Structure Click here
A0A1D6IKV8 View 3D Structure Click here
A0A1D6IKV9 View 3D Structure Click here
A0A1D6IKW0 View 3D Structure Click here
A0A1D6IKW1 View 3D Structure Click here
A0A1D6IKW2 View 3D Structure Click here
A0A1D6IKX3 View 3D Structure Click here
A0A1D6IMZ0 View 3D Structure Click here
A0A1D6IN00 View 3D Structure Click here
A0A1D6IN01 View 3D Structure Click here
A0A1D6IU85 View 3D Structure Click here
A0A1D6IYE4 View 3D Structure Click here
A0A1D6J1L2 View 3D Structure Click here
A0A1D6J6Y4 View 3D Structure Click here
A0A1D6JF04 View 3D Structure Click here
A0A1D6JNY2 View 3D Structure Click here
A0A1D6JVC3 View 3D Structure Click here
A0A1D6JYW6 View 3D Structure Click here
A0A1D6K431 View 3D Structure Click here
A0A1D6K433 View 3D Structure Click here
A0A1D6K434 View 3D Structure Click here
A0A1D6K8V8 View 3D Structure Click here
A0A1D6KAW3 View 3D Structure Click here
A0A1D6KJ53 View 3D Structure Click here
A0A1D6KK78 View 3D Structure Click here
A0A1D6KQI0 View 3D Structure Click here
A0A1D6KUF0 View 3D Structure Click here
A0A1D6L5P7 View 3D Structure Click here
A0A1D6LE55 View 3D Structure Click here
A0A1D6LFH4 View 3D Structure Click here
A0A1D6LS36 View 3D Structure Click here
A0A1D6LWY7 View 3D Structure Click here
A0A1D6LYW3 View 3D Structure Click here
A0A1D6MRI4 View 3D Structure Click here
A0A1D6MRI5 View 3D Structure Click here
A0A1D6MSC0 View 3D Structure Click here
A0A1D6MYJ1 View 3D Structure Click here
A0A1D6MZX6 View 3D Structure Click here
A0A1D6N0K1 View 3D Structure Click here
A0A1D6N0K3 View 3D Structure Click here
A0A1D6N9N4 View 3D Structure Click here
A0A1D6NGC5 View 3D Structure Click here
A0A1D6NYM3 View 3D Structure Click here
A0A1D6NZH6 View 3D Structure Click here
A0A1D6QGI0 View 3D Structure Click here
A0A1D6QMU5 View 3D Structure Click here
A0A1D6QSQ3 View 3D Structure Click here
A0A368UK63 View 3D Structure Click here
A0A368UKK5 View 3D Structure Click here
A4HZF3 View 3D Structure Click here
A4I9H5 View 3D Structure Click here
A4IBN6 View 3D Structure Click here
A5H452 View 3D Structure Click here
A5H453 View 3D Structure Click here
A5H454 View 3D Structure Click here
A5H8G4 View 3D Structure Click here
B0M196 View 3D Structure Click here
B4F7T9 View 3D Structure Click here
B4F8B7 View 3D Structure Click here
B4FA32 View 3D Structure Click here
B4FBC8 View 3D Structure Click here
B4FBH0 View 3D Structure Click here
B4FG25 View 3D Structure Click here
B4FG39 View 3D Structure Click here
B4FH35 View 3D Structure Click here
B4FH68 View 3D Structure Click here
B4FHG3 View 3D Structure Click here
B4FHN3 View 3D Structure Click here
B4FK56 View 3D Structure Click here
B4FK72 View 3D Structure Click here
B4FKG0 View 3D Structure Click here
B4FKV6 View 3D Structure Click here
B4FNL8 View 3D Structure Click here
B4FRD6 View 3D Structure Click here
B4FSW5 View 3D Structure Click here
B4FTQ3 View 3D Structure Click here
B4FU88 View 3D Structure Click here
B4FUT1 View 3D Structure Click here
B4FVT1 View 3D Structure Click here
B4FVT4 View 3D Structure Click here
B4FY83 View 3D Structure Click here
B4FYD8 View 3D Structure Click here
B4FYH1 View 3D Structure Click here
B4FZR9 View 3D Structure Click here
B4G031 View 3D Structure Click here
B4G0X5 View 3D Structure Click here
B4G1C4 View 3D Structure Click here
B6SIA9 View 3D Structure Click here
B6SIU4 View 3D Structure Click here
B6SRR3 View 3D Structure Click here
B6T3V1 View 3D Structure Click here
B6TU39 View 3D Structure Click here
B6TWB1 View 3D Structure Click here
B8A1T1 View 3D Structure Click here
C0HFN4 View 3D Structure Click here
C0HGH8 View 3D Structure Click here
C0HHA6 View 3D Structure Click here
C0HIT1 View 3D Structure Click here
C0P4S1 View 3D Structure Click here
C0P813 View 3D Structure Click here
C0PKS1 View 3D Structure Click here
C0PPB6 View 3D Structure Click here
C4IZA5 View 3D Structure Click here
C4J6E4 View 3D Structure Click here
C4J9K0 View 3D Structure Click here
C6TCA1 View 3D Structure Click here
C6TED1 View 3D Structure Click here
C6TEG1 View 3D Structure Click here
C6TG60 View 3D Structure Click here
C6TH77 View 3D Structure Click here
C6THF9 View 3D Structure Click here
C6THP4 View 3D Structure Click here
C6TL64 View 3D Structure Click here
C7IZT8 View 3D Structure Click here
C7J4Z6 View 3D Structure Click here
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