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120  structures 3019  species 1  interaction 6221  sequences 68  architectures

Family: Asparaginase_2 (PF01112)

Summary: Asparaginase

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Asparaginase Edit Wikipedia article

Asparaginase
3eca.jpg
Clinical data
Trade namesElspar, others
Other namescrisantaspase, colaspase
AHFS/Drugs.comMonograph
MedlinePlusa682046
License data
Pregnancy
category
  • AU: D
  • US: C (Risk not ruled out)
Routes of
administration
IM or IV
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life39-49 hours (IM), 8-30 hours (IV)
Identifiers
CAS Number
IUPHAR/BPS
DrugBank
ChemSpider
  • none
UNII
KEGG
ECHA InfoCard100.029.774 Edit this at Wikidata
Chemical and physical data
FormulaC1377H2208N382O442S17
Molar mass31731.9 g/mol g·mol−1
 â˜’N☑Y (what is this?)  (verify)

Asparaginase is an enzyme that is used as a medication and in food manufacturing.[1][2] As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and non-Hodgkin's lymphoma.[1] It is given by injection into a vein, muscle, or under the skin.[1] A pegylated version is also available.[3] In food manufacturing it is used to decrease acrylamide.[2]

Common side effects when used by injection include allergic reactions, pancreatitis, blood clotting problems, high blood sugar, kidney problems, and liver dysfunction.[1] Use in pregnancy may harm the baby.[4] As a food it is generally recognized as safe.[2] Asparaginase works by breaking down the amino acid known as asparagine without which the cancer cells cannot make protein.[1]

Asparaginase was approved for medical use in the United States in 1978.[3] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[5] The wholesale cost in the developing world is about US$42.00 per 10,000 IU vial.[6] This amount in the United Kingdom costs the NHS 613.00 pounds.[7] It is often made from Escherichia coli or Erwinia chrysanthemi.[3][8]