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153  structures 5034  species 1  interaction 16995  sequences 47  architectures

Family: CoA_trans (PF01144)

Summary: Coenzyme A transferase

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Coenzyme A transferase Provide feedback

No Pfam abstract.

Literature references

  1. Jacob U, Mack M, Clausen T, Huber R, Buckel W, Messerschmidt A; , Structure 1997;5:415-426.: Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases. PUBMED:9083111 EPMC:9083111


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR004165

Coenzyme A (CoA) transferases belong to an evolutionary conserved [PUBMED:1624453, PUBMED:9325289] family of enzymes catalyzing the reversible transfer of CoA from one carboxylic acid to another. They have been identified in many prokaryotes and in mammalian tissues. The bacterial enzymes are heterodimer of two subunits (A and B) of about 25 Kd each while eukaryotic SCOT consist of a single chain which is colinear with the two bacterial subunits.

CoA-transferases are found in organisms from all kingdoms of life. They catalyse reversible transfer reactions of coenzyme A groups from CoA-thioesters to free acids. There are at least three families of CoA-transferases, which differ in sequence and reaction mechanism:

  • Family I consists of CoA-transferases for 3-oxoacids (EC, EC), short-chain fatty acids (EC, EC) and glutaconate (EC). Most use succinyl-CoA or acetyl-CoA as CoA donors.
  • Family II consists of the homodimeric alpha-subunits of citrate lyase and citramalate lyase (EC, EC). These enzymes catalyse the transfer of acyl carrier protein (ACP) with a covalently bound CoA derivative, but can accept free CoA thioesters as well.
  • Family III consists of formyl-CoA:oxalate CoA-transferase [PUBMED:15213226], succinyl-CoA:(R)-benzylsuccinate CoA-transferase [PUBMED:11418570], (E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase [PUBMED:10849007], and butyrobetainyl-CoA:(R)-carnitine CoA-transferase [PUBMED:15823031]. These CoA-transferases occur in prokaryotes and eukaryotes, and catalyse CoA-transfer reactions in a highly substrate- and stereo-specific manner [PUBMED:11749953].
This family consists of 3-oxoacid CoA-transferases and related CoA-transferases from family I.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan ISOCOT_Fold (CL0246), which has the following description:

This superfamily contains a variety of enzymes and non-enzymatic ligand binding domains.

The clan contains the following 12 members:

5-FTHF_cyc-lig AcetylCoA_hyd_C AcetylCoA_hydro CitF CoA_trans DeoRC Glucosamine_iso IF-2B LUD_dom Mal_decarbox_Al Rib_5-P_isom_A Sugar-bind

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(40)
Full
(16995)
Representative proteomes UniProt
(45472)
NCBI
(58751)
Meta
(1105)
RP15
(3471)
RP35
(10277)
RP55
(16683)
RP75
(24452)
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