Summary: tRNA-splicing endonuclease subunit sen54 N-term
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tRNA-splicing endonuclease subunit sen54 N-term Provide feedback
This is an N-terminal family of archaeal and metazoan sen54 proteins that forms one of the tRNA-splicing endonuclease subunits.
Internal database links
|Similarity to PfamA using HHSearch:||tRNA_int_endo_N|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR024336
tRNA-splicing endonucleases (EC) catalyse the endonucleolytic cleavage of pre tRNA at the 5' and 3' splice sites to release the intron and produces two half tRNA molecules bearing 5' hydroxyl and 2', 3'-cyclic phosphate termini [PUBMED:9321408, PUBMED:9200603]. The genes encoding these proteins are homologous in eukaryotes and archea. The eukaryotic tRNA-splicing endonucleases are heterotetrameric while the archaeal endonucleases can be split into homodimeric and homotetrameric subgroups.This entry represents the N-terminal domain of Sen54, a non-catalytic subunit of the tRNA-splicing endonuclease complex. Defects in human Sen54 are a cause of pontocerebellar hypoplasia type 4 [PUBMED:18711368].
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Curation and family details
|Seed source:||Pfam-B_644 (release 24.0)|
|Author:||Wood V, Coggill P|
|Number in seed:||49|
|Number in full:||270|
|Average length of the domain:||78.90 aa|
|Average identity of full alignment:||30 %|
|Average coverage of the sequence by the domain:||17.41 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
|Download:||download the raw HMM for this family|
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