Summary: Zinc-finger double-stranded RNA-binding
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This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localise in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localisation.
Internal database links
|Similarity to PfamA using HHSearch:||zf-C2H2 zf-U1 zf-DBF zf-C2H2_2 zf-met zf-C2H2_4 zf-C2H2_6 zf-C2HC_2|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR022755
This zinc finger is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localise in the nucleus, particularly the nucleolus [PUBMED:10488071]. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localisation.
This entry represents the multiple-adjacent-C2H2 zinc finger, JAZ.
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Superfamily of classical and closely related C2H2 or beta-beta-alpha zinc finger DNA-binding domains.
The clan contains the following 19 members:4F5 DUF3449 GAGA Sgf11 zf-AD zf-BED zf-C2H2 zf-C2H2_2 zf-C2H2_4 zf-C2H2_6 zf-C2H2_7 zf-C2H2_jaz zf-C2HC_2 zf-Di19 zf-H2C2_2 zf-H2C2_5 zf-met zf-met2 zf-U1
We make a range of alignments for each Pfam-A family:
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- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
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Curation and family details
|Seed source:||PFAM-B_2302 (release 23.0)|
|Author:||Assefa S, Bateman A, Coggill P|
|Number in seed:||140|
|Number in full:||2095|
|Average length of the domain:||26.70 aa|
|Average identity of full alignment:||31 %|
|Average coverage of the sequence by the domain:||6.11 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the zf-C2H2_jaz domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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