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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: A1Z8U0_DROME (A1Z8U0)

Summary

This is the summary of UniProt entry A1Z8U0_DROME (A1Z8U0).

Description: Pre-mRNA processing factor 8 {ECO:0000313|EMBL:AAF58573.1}
Source organism: Drosophila melanogaster (Fruit fly) (NCBI taxonomy ID 7227)
Length: 2396 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 24
low_complexity n/a 10 46
disorder n/a 25 88
low_complexity n/a 47 58
low_complexity n/a 62 80
disorder n/a 111 114
disorder n/a 116 117
Pfam PRO8NT 118 269
disorder n/a 122 135
low_complexity n/a 210 226
low_complexity n/a 226 235
disorder n/a 422 423
disorder n/a 425 435
low_complexity n/a 429 443
Pfam PROCN 455 861
Pfam RRM_4 1046 1137
low_complexity n/a 1050 1059
low_complexity n/a 1105 1115
disorder n/a 1172 1173
Pfam U5_2-snRNA_bdg 1270 1403
coiled_coil n/a 1451 1471
Pfam U6-snRNA_bdg 1502 1660
Pfam PRP8_domainIV 1820 2049
disorder n/a 2083 2121
low_complexity n/a 2100 2107
Pfam JAB 2159 2265
disorder n/a 2202 2204
disorder n/a 2216 2217
disorder n/a 2240 2241
disorder n/a 2248 2254
disorder n/a 2259 2260
Pfam PROCT 2272 2394
disorder n/a 2297 2304
disorder n/a 2306 2311
low_complexity n/a 2381 2393
disorder n/a 2388 2389
disorder n/a 2391 2393

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A1Z8U0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSIPPYMIPQ NAWAAQLMAQ QAYAAAHAQQ AQLHAQQQMA NQIQQIPPPG
50
51
APLPPAGGHT NGIPIPVGGQ GPGLGQIPTP KPDILTEEKL QEKALKWQHL
100
101
QSKRFAEKRK FGFVDTQKED MPPEHIRKII RDHGDMTSRK YRHDKRVYLG
150
151
ALKYMPHAVL KLLENMPMPW EQIRDVQVLY HITGAITFVN EIPWVIEPVY
200
201
IAQWGTMWIM MRREKRDRRH FKRMRFPPFD DEEPPLDYAD NVLDVEPLEA
250
251
IQIELDNDED NAVYKWFYDH RPLVDTQFVN GTTYRKWNLS LPQLATLYRL
300
301
ANQLLTDLVD NNFFYLFDPK SFFTAKALNM AIPGGPKFEP LIKDHNVGDE
350
351
DWNEFNDINK VIIRQPIRTE YRIAFPYLYN NMPHFVHLSW YHTPNVVYIK
400
401
TEDPDLPAFY FDPLINPISH RNANSKIQEP LPDDDEDFTL PDDVQPFLQD
450
451
TPLYTDNTAN GIALLWAPRP FNMRSGRSRR AIDVPLVKCW YKEHCPPGHP
500
501
VKVRVSYQKL LKYYVLNALK HRKPKPQKKR YLFRSFKATK FFQTTTLDWV
550
551
EAGLQVCRQG YNMLNLLIHR KNLNYLHLDY NFNLKPVKTL TTKERKKSRF
600
601
GNAFHLCREI LRLTKLIIDS HVQYRLNNVD AFQLADGLQY IFAHVGQLTG
650
651
MYRYKYKLMR QIRMCKDLKH LIYYRFNTGP VGKGPGCGFW APGWRVWLFF
700
701
MRGITPLLER WLGNLLSRQF EGRHSKGVAK TVTKQRVESH FDLELRASVM
750
751
HDIVDMMPEG IKQNKARTIL QHLSEAWRCW KANIPWKVPG LPIPIENMIL
800
801
RYVKMKADWW TNTAHYNRER IRRGATVDKT VCKKNLGRLT RLYLKAEQER
850
851
QHNYLKDGPY ISPEEAVAIY TTTVHWLESR RFAPIPFPPL SYKHDTKLLI
900
901
LALERLKEAY SVKSRLNQSQ REELGLIEQA YDNPHEALSR IKRHLLTQRA
950
951
FKEVGIEFMD LYSHLIPVYE VEPLEKITDA YLDQYLWYEA DKRRLFPPWI
1000
1001
KPSDTEPPPL LAYKWCQGIN NLQDVWDVGE GECNVLLESR FEKLYEKIDL
1050
1051
TLLNRLLRLI VDHNIADYMT AKNNVVINYK DMNHTNSYGI IRGLQFSSFI
1100
1101
TQYYGLVLDL LVLGLHRSSE MAGPPQMPND FLTFQDTVTE TAHPIRLYCR
1150
1151
YVDRIHLFFR FSAEEARDLI QRYLTEHPDP NNENIVGYNN KKCWPRDARM
1200
1201
RLMKHDVNLG RAVFWDIKNR LPRSVTTIGW ESTFVSVYSK DNPNLLFNMS
1250
1251
GFECRILPKC RTQNEEFTHR DGVWNLQNEI TKERTAQCFL RVDDESLGRF
1300
1301
HNRVRQILMA SGSTTFTKIV NKWNTALIGL MTYFREAVVN TQELLDLLVK
1350
1351
CENKIQTRIK IGLNSKMPSR FPPVVFYTPK ELGGLGMLSM GHVLIPQSDL
1400
1401
RWSKQTDVGI THFRSGMSHD EDQLIPNLYR YIQPWESEFI DSQRVWAEYA
1450
1451
LKRQEANAQN RRLTLEDLED SWDRGIPRIN TLFQKDRHTL AYDKGWRIRT
1500
1501
EFKQYQVLKQ NPFWWTHQRH DGKLWNLNNY RTDMIQALGG VEGILEHTLF
1550
1551
KGTYFPTWEG LFWEKASGFE ESMKYKKLTN AQRSGLNQIP NRRFTLWWSP
1600
1601
TINRANVYVG FQVQLDLTGI FMHGKIPTLK ISLIQIFRAH LWQKIHESIV
1650
1651
MDLCQVFDQE LDALEIETVQ KETIHPRKSY KMNSSCADIL LFPAYKWNVS
1700
1701
RPSLLADTKD TMDNTTTQKY WLDIQLRWGD YDSHDVERYA RAKFLDYTTD
1750
1751
NMSIYPSPTG VLIAIDLAYN LHSAYGNWFP GCKTLIQQAM AKIMKANPAL
1800
1801
YVLRERIRKA LQLYSSEPTE PYLSSQNYGE LFSNQIIWFV DDTNVYRVTI
1850
1851
HKTFEGNLTT KPINGAIFIF NPRTGQLFLK IIHTSVWAGQ KRLGQLAKWK
1900
1901
TAEEVAALIR SLPVEEQPKQ IIVTRKGMLD PLEVHLLDFP NIVIKGSELQ
1950
1951
LPFQACLKVE KFGDLILKAT EPQMVLFNLY DDWLKTISSY TAFSRLILIL
2000
2001
RALHVNTERT KIILKPDKTT ITEAHHIWPT LTDEEWIKVE VQLKDLILAD
2050
2051
YGKKNNVNVA SLTQSEIRDI ILGMEISAPS AQRQQIAEIE KQTKEQNQLT
2100
2101
ATTTRTTNKH GDEIITSTTS NYETQTFSSK TEWRVRAISA TNLHLRTNHI
2150
2151
YVSSDDIKET GYTYILPKNI LKKFVTISDL RAQIAGYLYG VSPPDNPQVK
2200
2201
EIRCIVMPPQ WGTHQTINLP NTLPTHQYLK DMEPLGWIHT QPNELPQLSP
2250
2251
QDITTHAKIM QENSNWDGEK TIVITCSFTP GSCSLTAYKL TPSGFEWGSK
2300
2301
NTDKGNNPKG YLPSHYERVQ MLLSNKFLGF FMVPAQSSWN YNFMGVRHDP
2350
2351
NMKYELQLAN PKEFYHELHR TSHFLLFSNL EDGGDGAGAD REDVYA    
2396
 

Show the unformatted sequence.

Checksums:
CRC64:237F97421293E6CC
MD5:2126edc39c297a41431d0a901d104bd6

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;