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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: PK2L1_MOUSE (A2A259)

Summary

This is the summary of UniProt entry PK2L1_MOUSE (A2A259).

Description: Polycystic kidney disease 2-like 1 protein
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
Length: 760 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 26
disorder n/a 49 57
transmembrane n/a 104 129
Pfam PKD_channel 145 567
transmembrane n/a 350 368
low_complexity n/a 354 369
low_complexity n/a 387 400
transmembrane n/a 388 406
transmembrane n/a 477 499
low_complexity n/a 538 550
transmembrane n/a 539 560
low_complexity n/a 591 597
disorder n/a 649 667
coiled_coil n/a 652 679
disorder n/a 673 695
Pfam Fer4_24 699 733
disorder n/a 734 756

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A2A259. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNSMESPKNQ ELQTLGNRAW DNPAYSDPPS PNRTLRICTV SSVALPETQP
50
51
KKPEVRCQEK TQRTLVSSCC LHICRSIRGL WGTTLTENTA ENRELYVKTT
100
101
LRELVVYIVF LVDICLLTYG MTSSSAYYYT KVMSELFLHT PSDSGVSFQT
150
151
ISSMSDFWDF AQGPLLDSLY WTKWYNNQSL GRGSHSFIYY ENLLLGAPRL
200
201
RQLRVRNDSC VVHEDFREDI LNCYDVYSPD KEDQLPFGPQ NGTAWTYHSQ
250
251
NELGGSSHWG RLTSYSGGGY YLDLPGSRQA SAEALQGLQE GLWLDRGTRV
300
301
VFIDFSVYNA NINLFCILRL VVEFPATGGT IPSWQIRTVK LIRYVNNWDF
350
351
FIVGCEVVFC VFIFYYVVEE ILEIHLHRLR YLSSVWNILD LVVILLSIVA
400
401
VGFHIFRTLE VNRLMGKLLQ QPDTYADFEF LAFWQTQYNN MNAVNLFFAW
450
451
IKIFKYISFN KTMTQLSSTL ARCAKDILGF AIMFFIVFFA YAQLGYLLFG
500
501
TQVENFSTFV KCIFTQFRII LGDFDYNAID NANRILGPVY FVTYVFFVFF
550
551
VLLNMFLAII NDTYSEVKEE LAGQKDQLQL SDFLKQSYNK TLLRLRLRKE
600
601
RVSDVQKVLK GGEPEIQFED FTSTLRELGH EEHEITAAFT RFDQDGDHIL
650
651
DEEEQEQMRQ GLEEERVTLN AEIENLGRSV GHSPPGELGA EAARGQSWVS
700
701
GEEFDMLTRR VLQLQCVLEG VVSQIDAVGS KLKMLERKGE LAPSPGMGEP
750
751
AVWENLYNPS                                            
760
 

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Checksums:
CRC64:4C76777051CFC2EF
MD5:64e61a21fe2a5187d329702af48589a6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PKD_channel 145 - 563 5Z1W A 145 - 563 Jmol OpenAstexViewer
B 145 - 563 Jmol OpenAstexViewer
C 145 - 563 Jmol OpenAstexViewer
D 145 - 563 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.