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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CHD5_MOUSE (A2A8L1)

Summary

This is the summary of UniProt entry CHD5_MOUSE (A2A8L1).

Description: Chromodomain-helicase-DNA-binding protein 5 EC=3.6.4.12
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
Length: 1946 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 140
low_complexity n/a 17 29
low_complexity n/a 27 40
low_complexity n/a 46 71
coiled_coil n/a 65 85
low_complexity n/a 76 92
coiled_coil n/a 96 123
low_complexity n/a 97 133
Pfam CHDNT 149 203
disorder n/a 178 179
disorder n/a 181 183
low_complexity n/a 209 220
disorder n/a 227 272
low_complexity n/a 256 273
disorder n/a 286 309
low_complexity n/a 291 304
disorder n/a 314 315
disorder n/a 319 320
low_complexity n/a 323 333
disorder n/a 328 336
Pfam PHD 347 392
disorder n/a 397 398
disorder n/a 400 411
low_complexity n/a 400 416
Pfam PHD 420 465
disorder n/a 488 503
low_complexity n/a 488 512
disorder n/a 552 565
disorder n/a 567 573
Pfam Chromo 594 646
low_complexity n/a 657 678
disorder n/a 666 670
disorder n/a 672 676
disorder n/a 678 682
Pfam SNF2-rel_dom 705 1001
low_complexity n/a 881 895
low_complexity n/a 1023 1038
Pfam Helicase_C 1026 1140
disorder n/a 1181 1182
disorder n/a 1206 1256
disorder n/a 1267 1284
coiled_coil n/a 1296 1316
low_complexity n/a 1296 1310
Pfam DUF1087 1300 1360
disorder n/a 1302 1315
low_complexity n/a 1303 1315
disorder n/a 1317 1318
disorder n/a 1321 1329
disorder n/a 1332 1346
disorder n/a 1348 1411
low_complexity n/a 1379 1387
Pfam CHDII_SANT-like 1390 1531
low_complexity n/a 1391 1401
disorder n/a 1452 1454
disorder n/a 1483 1494
disorder n/a 1523 1698
low_complexity n/a 1552 1567
low_complexity n/a 1685 1701
Pfam CHDCT2 1730 1876
disorder n/a 1841 1847
coiled_coil n/a 1852 1872
disorder n/a 1897 1946

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A2A8L1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRGPLGTEEE LPRLFAEEME NEEEMSEEED GGLEGFEDFF PAEPVSLPKK
50
51
KPKKLKESKS SKGKRKKKEG SNDEMSDNEE DLEEKSESEG SDYSPTKKKK
100
101
KKLKEKKEKK EKKEKRKKRG EDEDDNDDGG LKEPKSSGQL MAEWGLDDVD
150
151
YLFSEDDYHT LTNYKAFSQF LRPLIAKKNP KIPMSKMMTV LGAKWREFSA
200
201
NNPFKGSSAA AAAAAVAAAV ETVTIAPPLA ISPQQVPQTL PIRKAKTKEG
250
251
KGPGVRKKNK GAKDSKKKGR GKRVAGLKFR FGGISKRKKG SSSEEDERED
300
301
SDLDNASIHS SSVRSECSAA LGKKNKRRRK KKRIDDGDGY ETDHQDYCEV
350
351
CQQGGEIILC DTCPRAYHLV CLDPELEKAP EGKWSCPHCE KEGIQWEPKD
400
401
DDEEEEEGGC EEEEDDHMEF CRVCKDGGEL LCCDACPSSY HLHCLNPPLP
450
451
EIPNGEWLCP RCTCPPLKGK VQRILHWRWT EPPAPFVVGL PGPEVEPGMP
500
501
PPRPLEGIPE REFFVKWAGL SYWHCSWVKE LQLELYHTVM YRNYQRKNDM
550
551
DEPPPFDYGS GDEDGKSEKR KNKDPLYAKM EERFYRYGIK PEWMMVHRIL
600
601
NHSFDKKGDI HYLIKWKDLP YDQCTWEIDE IDIPYYDNLK QAYWGHRELM
650
651
LGEDARLPKR LVKKGKKLKD DKQEKPPDTP IVDPTVKFDK QPWYIDATGG
700
701
TLHPYQLEGL NWLRFSWAQG TDTILADEMG LGKTVQTIVF LYSLYKEGHS
750
751
KGPYLVSAPL STIINWEREF EMWAPDFYVV TYTGDKESRS VIRENEFSFE
800
801
DNAIRGGKKV FRMKKEVQIK FHVLLTSYEL ITIDQAILGS IEWACLVVDE
850
851
AHRLKNNQSK FFRVLNSYKI DYKLLLTGTP LQNNLEELFH LLNFLTPERF
900
901
NNLEGFLEEF ADISKEDQIK KLHDLLGPHM LRRLKADVFK NMPAKTELIV
950
951
RVELSQMQKK YYKFILTRNF EALNSKGGGN QVSLLNIMMD LKKCCNHPYL
1000
1001
FPVAAVEAPV LPNGSYDGSS LVKSSGKLML LQKMLKKLRD EGHRVLIFSQ
1050
1051
MTKMLDLLED FLEYEGYKYE RIDGGITGGL RQEAIDRFNA PGAQQFCFLL
1100
1101
STRAGGLGIN LATADTVIIY DSDWNPHNDI QAFSRAHRIG QNKKVMIYRF
1150
1151
VTRASVEERI TQVAKRKMML THLVVRPGLG SKSGSMTKQE LDDILKFGTE
1200
1201
ELFKDDVEGM MSQGQRPTTP IPDIQSTKGG SLTAGAKKKH GSTPPGDNKD
1250
1251
VEDSSVIHYD DAAISKLLDR NQDATDDTEL QNMNEYLSSF KVAQYVVREE
1300
1301
DGVEEVEREV IKQEENVDPD YWEKLLRHHY EQQQEDLARN LGKGKRIRKQ
1350
1351
VNYNDASQED QEWQDELSDN QSEYSIGSED EDEDFEERPE GQSGRRQSRR
1400
1401
QLKSDRDKPL PPLLARVGGN IEVLGFNARQ RKAFLNAIMR WGMPPQDAFN
1450
1451
SHWLVRDLRG KSEKEFRAYV SLFMRHLCEP GADGAETFAD GVPREGLSRQ
1500
1501
HVLTRIGVMS LVRKKVQEFE HVNGKYSTPD LVPEGAEGKK PGEVISSDPN
1550
1551
TPVPASPAQL PPAPLGLTDK MEAQLGYTDE KESGMQKPKK SLEIQTLPTA
1600
1601
LDRVEGEDKH QSSDSKDRAR EERTEEVEKA QGSPEQPLKE EVLPDKEPIP
1650
1651
DKPELSLGHS GDFRPDDPKT EEKEPGETQQ NGDREEDEEG KKEDKNGKFK
1700
1701
FMFNIADGGF TELHTLWQNE ERAAVSSGKI YEIWHRRHDY WLLAGIVTHG
1750
1751
YARWQDIQND PRYMILNEPF KSEIHKGNYL EMKNKFLARR FKLLEQALVI
1800
1801
EEQLRRAAYL NMTQDPNHPA MALNARLAEV ECLAESHQHL SKESLAGNKP
1850
1851
ANAVLHKVLN QLEELLSDMK ADVTRLPSML SRIPPVAARL QMSERSILSR
1900
1901
LTNRAGDPTI QQTSSRRRDF PLFQRSFPAE PSHLPNPRGR EKLQPF    
1946
 

Show the unformatted sequence.

Checksums:
CRC64:5B94AB11A9C9BB03
MD5:d3e24fdccbbac523fc7e7e142d31619f

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;