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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RHG42_HUMAN (A6NI28)

Summary

This is the summary of UniProt entry RHG42_HUMAN (A6NI28).

Description: Rho GTPase-activating protein 42 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 874 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam BAR_3 6 249
coiled_coil n/a 87 107
low_complexity n/a 125 143
disorder n/a 160 163
low_complexity n/a 182 198
coiled_coil n/a 225 259
disorder n/a 243 244
disorder n/a 246 248
disorder n/a 250 254
Pfam PH 266 371
Pfam RhoGAP 396 545
disorder n/a 575 602
disorder n/a 608 726
low_complexity n/a 617 630
low_complexity n/a 633 650
low_complexity n/a 726 744
disorder n/a 731 732
disorder n/a 736 742
disorder n/a 744 745
disorder n/a 752 786
disorder n/a 810 813
disorder n/a 820 823
Pfam SH3_9 823 872

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A6NI28. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGLPTLEFSD SYLDSPDFRE RLQCHEIELE RTNKFIKELI KDGSLLIGAL
50
51
RNLSMAVQKF SQSLQDFQFE CIGDAETDDE ISIAQSLKEF ARLLIAVEEE
100
101
RRRLIQNAND VLIAPLEKFR KEQIGAAKDG KKKFDKESEK YYSILEKHLN
150
151
LSAKKKESHL QEADTQIDRE HQNFYEASLE YVFKIQEVQE KKKFEFVEPL
200
201
LSFLQGLFTF YHEGYELAQE FAPYKQQLQF NLQNTRNNFE STRQEVERLM
250
251
QRMKSANQDY RPPSQWTMEG YLYVQEKRPL GFTWIKHYCT YDKGSKTFTM
300
301
SVSEMKSSGK MNGLVTSSPE MFKLKSCIRR KTDSIDKRFC FDIEVVERHG
350
351
IITLQAFSEA NRKLWLEAMD GKEPIYTLPA IISKKEEMYL NEAGFNFVRK
400
401
CIQAVETRGI TILGLYRIGG VNSKVQKLMN TTFSPKSPPD IDIDIELWDN
450
451
KTITSGLKNY LRCLAEPLMT YKLHKDFIIA VKSDDQNYRV EAVHALVHKL
500
501
PEKNREMLDI LIKHLVKVSL HSQQNLMTVS NLGVIFGPTL MRAQEETVAA
550
551
MMNIKFQNIV VEILIEHYEK IFHTAPDPSI PLPQPQSRSG SRRTRAICLS
600
601
TGSRKPRGRY TPCLAEPDSD SYSSSPDSTP MGSIESLSSH SSEQNSTTKS
650
651
ASCQPREKSG GIPWIATPSS SNGQKSLGLW TTSPESSSRE DATKTDAESD
700
701
CQSVASVTSP GDVSPPIDLV KKEPYGLSGL KRASASSLRS ISAAEGNKSY
750
751
SGSIQSLTSV GSKETPKASP NPDLPPKMCR RLRLDTASSN GYQRPGSVVA
800
801
AKAQLFENVG SPKPVSSGRQ AKAMYSCKAE HSHELSFPQG AIFSNVYPSV
850
851
EPGWLKATYE GKTGLVPENY VVFL                            
874
 

Show the unformatted sequence.

Checksums:
CRC64:3828623C52C52629
MD5:5d0ddbf3f81c732a1517aae035978691

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;