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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: LIRA5_HUMAN (A6NI73)

Summary

This is the summary of UniProt entry LIRA5_HUMAN (A6NI73).

Description: Leukocyte immunoglobulin-like receptor subfamily A member 5
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 299 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 13
low_complexity n/a 22 32
Pfam Ig_2 46 135
disorder n/a 78 102
disorder n/a 242 251
disorder n/a 254 255
transmembrane n/a 266 284
low_complexity n/a 272 282
disorder n/a 295 299

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A6NI73. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAPWSHPSAQ LQPVGGDAVS PALMVLLCLG LSLGPRTHVQ AGNLSKATLW
50
51
AEPGSVISRG NSVTIRCQGT LEAQEYRLVK EGSPEPWDTQ NPLEPKNKAR
100
101
FSIPSMTEHH AGRYRCYYYS PAGWSEPSDP LELVVTGFYN KPTLSALPSP
150
151
VVTSGENVTL QCGSRLRFDR FILTEEGDHK LSWTLDSQLT PSGQFQALFP
200
201
VGPVTPSHRW MLRCYGSRRH ILQVWSEPSD LLEIPVSGAA DNLSPSQNKS
250
251
DSGTASHLQD YAVENLIRMG MAGLILVVLG ILIFQDWHSQ RSPQAAAGR 
299
 

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Checksums:
CRC64:F5EE25361D4E0F02
MD5:907abf8c33375e9052bdfd255f2dc158

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ig_2 46 - 135 2D3V A 5 - 94 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.