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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: U119B_HUMAN (A6NIH7)

Summary

This is the summary of UniProt entry U119B_HUMAN (A6NIH7).

Description: Protein unc-119 homolog B
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 251 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 17
sig_p n/a 1 23
low_complexity n/a 8 23
low_complexity n/a 18 35
disorder n/a 20 23
disorder n/a 25 26
disorder n/a 32 53
Pfam GMP_PDE_delta 88 247
low_complexity n/a 120 131
disorder n/a 122 130

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A6NIH7. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSGSNPKAAA AASAAGPGGL VAGKEEKKKA GGGVLNRLKA RRQAPHHAAD
50
51
DGVGAAVTEQ ELLALDTIRP EHVLRLSRVT ENYLCKPEDN IYSIDFTRFK
100
101
IRDLETGTVL FEIAKPCVSD QEEDEEEGGG DVDISAGRFV RYQFTPAFLR
150
151
LRTVGATVEF TVGDKPVSNF RMIERHYFRE HLLKNFDFDF GFCIPSSRNT
200
201
CEHIYEFPQL SEDVIRLMIE NPYETRSDSF YFVDNKLIMH NKADYAYNGG
250
251
Q                                                     
251
 

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Checksums:
CRC64:3041B68EE89B3BD4
MD5:db15b79e5b8514ca07d9e899a1daa302

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
GMP_PDE_delta 88 - 247 7OK6 AAA 80 - 236 Show 3D Structure View in InterPro
HHH 80 - 236 Show 3D Structure View in InterPro
7OK7 G 88 - 244 Show 3D Structure View in InterPro
H 88 - 244 Show 3D Structure View in InterPro
I 88 - 244 Show 3D Structure View in InterPro
J 88 - 244 Show 3D Structure View in InterPro
K 88 - 244 Show 3D Structure View in InterPro
L 88 - 244 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;