!!

Powering down the Pfam website
On October 5th, we will start redirecting the traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will be available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ELB3D_HUMAN (A6NLF2)

Summary

This is the summary of UniProt entry ELB3D_HUMAN (A6NLF2).

Description: Elongin-A3 member D
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 546 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 13 15
Pfam Med26 29 77
disorder n/a 29 31
disorder n/a 45 65
disorder n/a 74 270
low_complexity n/a 136 162
low_complexity n/a 196 217
low_complexity n/a 222 235
disorder n/a 288 318
disorder n/a 343 346
disorder n/a 348 349
Pfam Elongin_A 352 450
disorder n/a 353 355
disorder n/a 357 358
disorder n/a 369 385
disorder n/a 397 400
disorder n/a 409 417
disorder n/a 427 546
low_complexity n/a 494 510

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A6NLF2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAGSTTLRA VGKLQVRLAT KTEPKKLEKY LQKLSALPMT ADILAETGIR
50
51
KTVKRLRKHQ HVGDFARDLA ARWKKLVLVD RNTGPDPQDP EESASRQRFG
100
101
EALQEREKAW GFPENATAPR SPSHSPEHRR TARRTPPGQQ RPHPRSPSRE
150
151
PRAERKRPRM APADSGPHRD PPTRTAPLPM PEGPEPAVPG EQPGRGHAHA
200
201
AQGGPLLGQG CQGQPQGEAV GSHSKGHKSS RGASAQKSPP VQESQSERLQ
250
251
AAVADSAGPK TVPSHVFSEL WDPSEAWMQA NYDLLSAFEA MTSQANPEAL
300
301
SAPTLQEEAA FPGRRVNAKM PVYSGSRPAC QLQVPTLRQQ CLRVPRNNPD
350
351
ALGDVEGVPY SALEPVLEGW TPDQPYRTEK DNAALARETD ELWRIHCLQD
400
401
FKEEKPQEHE SWRELYLRLR DAREQRLRVV TTKIRSAREN KPSGRQTKMI
450
451
CFNSVAKTPY DASRRQEKSA GAADPGNGEM EPAPKPAGSS QAPSGLGDGD
500
501
GGSVSGGGSS NRHAAPADKT RKQAAKKVAP LMAKAIRDYK GRFSRR    
546
 

Show the unformatted sequence.

Checksums:
CRC64:00CB437E866753B3
MD5:f2fa9d88402fef9744c2b45b915d7d30

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;