Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: RHG32_HUMAN (A7KAX9)

Summary

This is the summary of UniProt entry RHG32_HUMAN (A7KAX9).

Description: Rho GTPase-activating protein 32
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 2087 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 6
disorder n/a 8 11
low_complexity n/a 29 35
disorder n/a 33 45
disorder n/a 49 76
Pfam SH3_9 266 317
disorder n/a 329 331
Pfam RhoGAP 386 538
disorder n/a 645 652
disorder n/a 671 739
disorder n/a 746 790
disorder n/a 794 795
disorder n/a 811 815
disorder n/a 818 820
disorder n/a 822 858
disorder n/a 861 871
disorder n/a 873 879
disorder n/a 881 883
disorder n/a 899 931
low_complexity n/a 924 937
disorder n/a 933 1081
low_complexity n/a 992 1004
low_complexity n/a 1015 1027
low_complexity n/a 1020 1035
low_complexity n/a 1042 1058
disorder n/a 1083 1086
disorder n/a 1088 1097
disorder n/a 1099 1366
low_complexity n/a 1255 1272
low_complexity n/a 1340 1351
disorder n/a 1369 1370
disorder n/a 1372 1397
disorder n/a 1405 1415
disorder n/a 1418 1431
low_complexity n/a 1424 1437
disorder n/a 1436 1443
disorder n/a 1452 1464
low_complexity n/a 1454 1463
disorder n/a 1466 1479
disorder n/a 1487 1488
disorder n/a 1502 1526
disorder n/a 1530 1546
disorder n/a 1548 1553
low_complexity n/a 1552 1564
disorder n/a 1580 1583
disorder n/a 1591 1592
disorder n/a 1594 1601
disorder n/a 1604 1606
disorder n/a 1610 1611
disorder n/a 1615 1616
disorder n/a 1628 1629
low_complexity n/a 1649 1662
disorder n/a 1718 1721
disorder n/a 1726 1727
disorder n/a 1729 1730
disorder n/a 1752 1777
disorder n/a 1787 1792
disorder n/a 1798 2011
disorder n/a 2014 2028
disorder n/a 2030 2065
low_complexity n/a 2037 2052
disorder n/a 2069 2087

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A7KAX9. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
METESESSTL GDDSVFWLES EVIIQVTDCE EEEREEKFRK MKSSVHSEED
50
51
DFVPELHRNV HPRERPDWEE TLSAMARGAD VPEIPGDLTL KTCGSTASMK
100
101
VKHVKKLPFT KGHFPKMAEC AHFHYENVEF GSIQLSLSEE QNEVMKNGCE
150
151
SKELVYLVQI ACQGKSWIVK RSYEDFRVLD KHLHLCIYDR RFSQLSELPR
200
201
SDTLKDSPES VTQMLMAYLS RLSAIAGNKI NCGPALTWME IDNKGNHLLV
250
251
HEESSINTPA VGAAHVIKRY TARAPDELTL EVGDIVSVID MPPKVLSTWW
300
301
RGKHGFQVGL FPGHCVELIN QKVPQSVTNS VPKPVSKKHG KLITFLRTFM
350
351
KSRPTKQKLK QRGILKERVF GCDLGEHLLN SGFEVPQVLQ SCTAFIERYG
400
401
IVDGIYRLSG VASNIQRLRH EFDSEHVPDL TKEPYVQDIH SVGSLCKLYF
450
451
RELPNPLLTY QLYEKFSDAV SAATDEERLI KIHDVIQQLP PPHYRTLEFL
500
501
MRHLSLLADY CSITNMHAKN LAIVWAPNLL RSKQIESACF SGTAAFMEVR
550
551
IQSVVVEFIL NHVDVLFSGR ISMAMQEGAA SLSRPKSLLV SSPSTKLLTL
600
601
EEAQARTQAQ VNSPIVTENK YIEVGEGPAA LQGKFHTIIE FPLERKRPQN
650
651
KMKKSPVGSW RSFFNLGKSS SVSKRKLQRN ESEPSEMKAM ALKGGRAEGT
700
701
LRSAKSEESL TSLHAVDGDS KLFRPRRPRS SSDALSASFN GEMLGNRCNS
750
751
YDNLPHDNES EEEGGLLHIP ALMSPHSAED VDLSPPDIGV ASLDFDPMSF
800
801
QCSPPKAESE CLESGASFLD SPGYSKDKPS ANKKDAETGS SQCQTPGSTA
850
851
SSEPVSPLQE KLSPFFTLDL SPTEDKSSKP SSFTEKVVYA FSPKIGRKLS
900
901
KSPSMSISEP ISVTLPPRVS EVIGTVSNTT AQNASSSTWD KCVEERDATN
950
951
RSPTQIVKMK TNETVAQEAY ESEVQPLDQV AAEEVELPGK EDQSVSSSQS
1000
1001
KAVASGQTQT GAVTHDPPQD SVPVSSVSLI PPPPPPKNVA RMLALALAES
1050
1051
AQQASTQSLK RPGTSQAGYT NYGDIAVATT EDNLSSSYSA VALDKAYFQT
1100
1101
DRPAEQFHLQ NNAPGNCDHP LPETTATGDP THSNTTESGE QHHQVDLTGN
1150
1151
QPHQAYLSGD PEKARITSVP LDSEKSDDHV SFPEDQSGKN SMPTVSFLDQ
1200
1201
DQSPPRFYSG DQPPSYLGAS VDKLHHPLEF ADKSPTPPNL PSDKIYPPSG
1250
1251
SPEENTSTAT MTYMTTTPAT AQMSTKEASW DVAEQPTTAD FAAATLQRTH
1300
1301
RTNRPLPPPP SQRSAEQPPV VGQVQAATNI GLNNSHKVQG VVPVPERPPE
1350
1351
PRAMDDPASA FISDSGAAAA QCPMATAVQP GLPEKVRDGA RVPLLHLRAE
1400
1401
SVPAHPCGFP APLPPTRMME SKMIAAIHSS SADATSSSNY HSFVTASSTS
1450
1451
VDDALPLPLP VPQPKHASQK TVYSSFARPD VTTEPFGPDN CLHFNMTPNC
1500
1501
QYRPQSVPPH HNKLEQHQVY GARSEPPASM GLRYNTYVAP GRNASGHHSK
1550
1551
PCSRVEYVSS LSSSVRNTCY PEDIPPYPTI RRVQSLHAPP SSMIRSVPIS
1600
1601
RTEVPPDDEP AYCPRPLYQY KPYQSSQARS DYHVTQLQPY FENGRVHYRY
1650
1651
SPYSSSSSSY YSPDGALCDV DAYGTVQLRP LHRLPNRDFA FYNPRLQGKS
1700
1701
LYSYAGLAPR PRANVTGYFS PNDHNVVSMP PAADVKHTYT SWDLEDMEKY
1750
1751
RMQSIRRESR ARQKVKGPVM SQYDNMTPAV QDDLGGIYVI HLRSKSDPGK
1800
1801
TGLLSVAEGK ESRHAAKAIS PEGEDRFYRR HPEAEMDRAH HHGGHGSTQP
1850
1851
EKPSLPQKQS SLRSRKLPDM GCSLPEHRAH QEASHRQFCE SKNGPPYPQG
1900
1901
AGQLDYGSKG IPDTSEPVSY HNSGVKYAAS GQESLRLNHK EVRLSKEMER
1950
1951
PWVRQPSAPE KHSRDCYKEE EHLTQSIVPP PKPERSHSLK LHHTQNVERD
2000
2001
PSVLYQYQPH GKRQSSVTVV SQYDNLEDYH SLPQHQRGVF GGGGMGTYVP
2050
2051
PGFPHPQSRT YATALGQGAF LPAELSLQHP ETQIHAE              
2087
 

Show the unformatted sequence.

Checksums:
CRC64:075E5B4902857D06
MD5:0a6003351447b8769aa55391b97b4629

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RhoGAP 386 - 532 3IUG A 386 - 532 Jmol OpenAstexViewer
B 386 - 532 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.