Summary
This is the summary of UniProt entry ADA33_HUMAN (Q9BZ11).
| Description: | Disintegrin and metalloproteinase domain-containing protein 33 EC=3.4.24.- |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 813 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 27 |
| low_complexity | n/a | 12 | 21 |
| Pfam | Pep_M12B_propep | 39 | 167 |
| low_complexity | n/a | 65 | 81 |
| low_complexity | n/a | 75 | 81 |
| disorder | n/a | 184 | 204 |
| Pfam | Reprolysin | 210 | 409 |
| disorder | n/a | 331 | 335 |
| Pfam | Disintegrin | 426 | 498 |
| Pfam | ADAM_CR | 503 | 619 |
| disorder | n/a | 690 | 693 |
| transmembrane | n/a | 702 | 725 |
| low_complexity | n/a | 702 | 720 |
| disorder | n/a | 748 | 809 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9BZ11. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MGWRPRRARG TPLLLLLLLL LLWPVPGAGV LQGHIPGQPV TPHWVLDGQP
50 51
WRTVSLEEPV SKPDMGLVAL EAEGQELLLE LEKNHRLLAP GYIETHYGPD
100 101
GQPVVLAPNH TDHCHYQGRV RGFPDSWVVL CTCSGMSGLI TLSRNASYYL
150 151
RPWPPRGSKD FSTHEIFRME QLLTWKGTCG HRDPGNKAGM TSLPGGPQSR
200 201
GRREARRTRK YLELYIVADH TLFLTRHRNL NHTKQRLLEV ANYVDQLLRT
250 251
LDIQVALTGL EVWTERDRSR VTQDANATLW AFLQWRRGLW AQRPHDSAQL
300 301
LTGRAFQGAT VGLAPVEGMC RAESSGGVST DHSELPIGAA ATMAHEIGHS
350 351
LGLSHDPDGC CVEAAAESGG CVMAAATGHP FPRVFSACSR RQLRAFFRKG
400 401
GGACLSNAPD PGLPVPPALC GNGFVEAGEE CDCGPGQECR DLCCFAHNCS
450 451
LRPGAQCAHG DCCVRCLLKP AGALCRQAMG DCDLPEFCTG TSSHCPPDVY
500 501
LLDGSPCARG SGYCWDGACP TLEQQCQQLW GPGSHPAPEA CFQVVNSAGD
550 551
AHGNCGQDSE GHFLPCAGRD ALCGKLQCQG GKPSLLAPHM VPVDSTVHLD
600 601
GQEVTCRGAL ALPSAQLDLL GLGLVEPGTQ CGPRMVCQSR RCRKNAFQEL
650 651
QRCLTACHSH GVCNSNHNCH CAPGWAPPFC DKPGFGGSMD SGPVQAENHD
700 701
TFLLAMLLSV LLPLLPGAGL AWCCYRLPGA HLQRCSWGCR RDPACSGPKD
750 751
GPHRDHPLGG VHPMELGPTA TGQPWPLDPE NSHEPSSHPE KPLPAVSPDP
800 801
QADQVQMPRS CLW
813
Show the unformatted sequence. |
| Checksums: |
CRC64:90713A99668D5569
MD5:d3d6bcaed1087d8cb568ebdc8e4e96d0
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Reprolysin | 210 - 409 | 1R54 | A | 210 - 409 | Jmol OpenAstexViewer |
| 1R55 | A | 210 - 409 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.