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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: E2AK4_RAT (D4A7V9)

Summary

This is the summary of UniProt entry E2AK4_RAT (D4A7V9).

Description: eIF-2-alpha kinase GCN2 {ECO:0000250|UniProtKB:Q9QZ05}
Source organism: Rattus norvegicus (Rat) (NCBI taxonomy ID 10116)
Length: 1649 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 26
low_complexity n/a 2 11
Pfam RWD 21 134
disorder n/a 41 47
disorder n/a 52 53
disorder n/a 88 94
disorder n/a 103 106
disorder n/a 132 253
coiled_coil n/a 147 201
low_complexity n/a 158 176
low_complexity n/a 178 199
Pfam Pkinase 305 539
coiled_coil n/a 326 346
low_complexity n/a 484 495
disorder n/a 545 552
disorder n/a 560 561
Pfam Pkinase 590 664
disorder n/a 659 713
disorder n/a 715 748
low_complexity n/a 729 739
disorder n/a 754 787
Pfam Pkinase 777 1001
disorder n/a 884 892
disorder n/a 960 968
disorder n/a 993 999
disorder n/a 1011 1014
Pfam tRNA-synt_His 1055 1381
low_complexity n/a 1245 1257
low_complexity n/a 1292 1311
Pfam HGTP_anticodon2 1393 1648
disorder n/a 1464 1466
low_complexity n/a 1528 1539

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession D4A7V9. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAGGRGAAGR GPAEPQESYS QRQDHELQAL EAIYGSDFQD LRPDARGRVR
50
51
EPPEINLVLY PQGLAGEEVY VQVELRVKCP PTYPDVVPEI ELKNTKGLSN
100
101
ESVNLLKSHL EELAKKQCGE VMIFELAHHV QSFLSEHNKP PPKSFHEEML
150
151
ERQAQEKQQR LLEARQKEEQ EQREILHEIQ KRKEEIKEEK KRKEMAKQER
200
201
LEITSLTNQD HASKRDPAGH RAAAFLHGGS PDFVGNGKAR AHSSGRSRRE
250
251
RQYSVCSGEA SPGSCDILYF CVGSADQLMV HKGKCVGSDE QLGKVVYNAL
300
301
ETATGSFVLL YEWVLQWQKK MGPCLTSQEK EKIDKCKKQI QGAETEFSSL
350
351
VKLSHPNIVR YFAMNSREEK DSIVVDILAE HISGISLAAH LSHSGPVPMH
400
401
QLRKYTAQLL AGLDYLHRNS VVHKVLSTAS VLVDAEGTVK ITDYSISKRL
450
451
ADICKEDVFE QTRVRFSDSA LPYKTGKKGD VWRLGLLLLS LSQGQECEEY
500
501
PVTIPSDLPA DFQDFLKKCV CLDDKERWSP QQLLKHSFIN PQPKMPLVEQ
550
551
SPEDSGGQDY IETIIPSNQL PSAAFFTETQ RQFSRYFIEF EELQLLGKGA
600
601
FGAVIKVQNK LDGCCYAVKR IPINPASRQF RRIKGEVTLL SRLHHENIVR
650
651
YYNAWIERHE RPAVPGTPPP DYIPQAQNSS ATGGKASGDT EELGSVEAAA
700
701
PPPILSSSVE WSTSAERSNS ARFPVTGQDS SSDEEDEDER DGVFSQSFLP
750
751
ASDSDSDIIF DNEDENSKSQ NQDEDCNEKD SRHEIEPSVT TEAVHYLYIQ
800
801
MEYCEKSTLR DTIDQGLFRD TSRLWRLFRE ILDGLAYIHE KGMIHRDLKP
850
851
VNIFLDSDDH VKIGDFGLAT DHLAFNAEGK QDDQAGDHVI KSDPSGHLTG
900
901
MVGTALYVSP EVQGSTKSAY NQKVDLFSLG IILFEMSYHP MVTASERIFV
950
951
LNQLRDPTSP KFPDDFEDGE HTKQKSVISW LLNHDPAKRP TAMELLKSEL
1000
1001
LPPPQMEESE LHEVLHHTLA NTDGKAYRTM MSQLFCQHSS PAIDYTYDSD
1050
1051
ILKGNFLIRT AKIQQLVCET IVRVFKRHGA VQLCTPLLLP RNRQIYEHNE
1100
1101
AALFMDHSGM LVMLPFDLRV PFARYVARNN ILNLKRYCIE RVFRPRKLDR
1150
1151
FHPKELLECA FDIVTSTANS SLPTAETIYT IYEVIQEFPA LQERNYSIYL
1200
1201
NHTMLLKAIL LHCGIPEDKL SQVYVILYDA VTEKLTRREV EAKFCNLSLS
1250
1251
SNSLCRLYKF IEQKGDLQDL TPTINSLIKQ KTGIAQLVKY SLKDLEEVVG
1300
1301
LLKKLGVKLQ VSINLGLVYK VQQHNGIIFQ FLAFSKRRQR VVPEILAAGG
1350
1351
RYDLLIPKFR GPQALGPVPT AVGVSIAIDK IFAAVLNMGE PVTVSSCDLL
1400
1401
VVSAGQMSMS RAINLTQKLW TAGITAEIMY DWSQSQEELQ EYCRHHEITY
1450
1451
VALVSDKEGS HVKVKSFEKE RQTEKRVLES DLVDHVMQKL RTKVGDERNF
1500
1501
RDASDNLAVQ TLKGSFSNAS GLFEIHGTTV VPTVSVISPE KLSASTRRRH
1550
1551
EIQVQTRLQT TLANLHQKSS EIEILAVDLP KETILQFLSL EWDADEQAFN
1600
1601
TTVKQLLSRL PKQRYLKLVC DEIYNIKVEK KVSVLFLYSY RDDYYRILF 
1649
 

Show the unformatted sequence.

Checksums:
CRC64:75D093684454115F
MD5:a5fadfd26163d58f5cfe6f2e7f6882f9

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;