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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: E7F5Y6_DANRE (E7F5Y6)

Summary

This is the summary of UniProt entry E7F5Y6_DANRE (E7F5Y6).

Description: Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133}
Source organism: Danio rerio (Zebrafish) (Brachydanio rerio) (NCBI taxonomy ID 7955)
Length: 694 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam PI-PLC-X 6 60
disorder n/a 34 148
low_complexity n/a 59 76
low_complexity n/a 114 128
Pfam PI-PLC-Y 148 262
Pfam C2 283 385
disorder n/a 321 322
disorder n/a 419 424
disorder n/a 428 430
disorder n/a 432 437
disorder n/a 445 609
low_complexity n/a 448 469
low_complexity n/a 460 477
low_complexity n/a 481 547
Pfam DUF1154 569 612
coiled_coil n/a 588 608
disorder n/a 613 694
low_complexity n/a 618 628
coiled_coil n/a 637 684
Pfam PLC-beta_C 638 694

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession E7F5Y6. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKCFFVCFRV KQQEKMANYC RTIFGDALLI DLLDKYPLKP GQPIPSPSEL
50
51
MGKILIKNKK SSAAPSKAEP SKKPAAQEQT SDPAEGSEAT QSTDATQPTP
100
101
NNPEGTDPPA ATGEDREEHD DHDEQDEEKM KNSDEGTAGQ EVTAYEEMSA
150
151
LVNYVQPNKF ISFENAAKKN RCFVISSFVE TKGESLIAKN AVDWVEYNKR
200
201
QLSRIYPKGT RVDSSNYSPQ PFWSAGCQFV ALNYQTMDFP MQLNMALFEF
250
251
NGRTGYLLKH DVMRRSDKKF DPFCDRIDTI IASTLTIKIY SGQFLSDKAV
300
301
KTGVEVELIG LPKDPKRKYR TKMSSTANGI NPDWNEEPFI FEKVLLPEMA
350
351
YLRLVVQEEG GKFIGHRIIP LDALQTGFQH IGLRSESNMP LMLPSLFVHI
400
401
EMKDYVPAAF ADFSDALFNP VKTSKPPKTE SLTYVCEYEL PLADGVQKAA
450
451
TAAPAAEPKE AESAETPAEG GAAPPAEQNT TETKPEEKPE PEAKPEPEPE
500
501
AKPEPESEAK PEPEPEPKPE EKTEPEPDPK PEEKVKAEPT PEETPEAVVD
550
551
AAVTETKESS EETPADPSDP ITVSCEELQQ HKNFLKVTKK QEKDLKDMEK
600
601
KFQKRREDLI QKYSDQFKAL KKKNSTKKNG AEGSDPADQM NELKQKLKSE
650
651
LRAVLVEQHD QLKKKKEQHN TERLTKLLET ATEKHCSEMK ALNR      
694
 

Show the unformatted sequence.

Checksums:
CRC64:0E274D9C9BA9F2C5
MD5:433f3c96d0d6c96579ae344c03b1a2db

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;