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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: F6XL78_HORSE (F6XL78)

Summary

This is the summary of UniProt entry F6XL78_HORSE (F6XL78).

Description: Amyloid beta precursor protein {ECO:0000313|Ensembl:ENSECAP00000019519}
Source organism: Equus caballus (Horse) (NCBI taxonomy ID 9796)
View Pfam proteome data.
Length: 751 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam APP_N 12 112
disorder n/a 30 31
Pfam APP_Cu_bd 113 169
low_complexity n/a 170 188
disorder n/a 176 197
disorder n/a 200 276
low_complexity n/a 202 247
coiled_coil n/a 209 229
low_complexity n/a 243 270
Pfam Kunitz_BPTI 271 323
disorder n/a 329 411
Pfam APP_E2 347 529
coiled_coil n/a 380 400
coiled_coil n/a 406 440
disorder n/a 415 441
disorder n/a 475 476
disorder n/a 490 495
coiled_coil n/a 536 556
disorder n/a 545 546
disorder n/a 572 575
disorder n/a 580 582
disorder n/a 606 611
disorder n/a 613 640
disorder n/a 642 644
Pfam Beta-APP 656 694
transmembrane n/a 682 704
low_complexity n/a 686 703
Pfam APP_amyloid 697 747
disorder n/a 728 734

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession F6XL78. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
VPTDGNAGLL AEPQIAMFCG KLNMHMNVQN GKWESDPSGT KTCIGTKEGI
50
51
LQYCQEVYPE LQITNVVEAN QPVTIQNWCK RGRKQCKTHA HIVIPYRCLV
100
101
GEFVSDALLV PDKCKFLHQE RMDVCETHLH WHTVAKETCS EKSTNLHDYG
150
151
MLLPCGIDKF RGVEFVCCPL AEESDNVDSA DAEEDDSDVW WGGADTDYAD
200
201
GSEDKVVEVA EEEDVADVEE EEAEDDEDDE DGDEVEEEAE EPYEEATERT
250
251
TSIATTTTTT TESVEEVVRE VCSEQAETGP CRAMISRWYF DVTEGKCAPF
300
301
FYGGCGGNRN NFDTEEYCMA VCGSVMSQSL LKTPQEPLPQ DPVKLPTTAA
350
351
STPDAVDKYL ETPGDENEHA HFQKAKERLE AKHRERMSQV MREWEEAERQ
400
401
AKNLPKADKK AVIQHFQEKV ESLEQEAANE RQQLVETHMA RVEAMLNDRR
450
451
RLALENYITA LQAVPPRPRH VFNMLKKYVR AEQKDRQHTL KHFEHVRMVD
500
501
PKKAAQIRSQ VMTHLRVIYE RMNQSLSLLY NVPAVAEEIQ DEVDELLQKE
550
551
QNYSDDVLAN MISEPRISYG NDALMPSLTE TKTTVELLPV NGEFSLDDLQ
600
601
PWHPFGVDSV PANTENEVEP VDARPAADRG LTTRPGSGLT NIKTEEISEV
650
651
KMDAEFRHDS GYEVHHQKLV FFAEDVGSNK GAIIGLMVGG VVIATVIVIT
700
701
LVMLKKKQYT SIHHGVVEVD AAVTPEERHL SKMQQNGYEN PTYKFFEQMQ
750
751
N                                                     
751
 

Show the unformatted sequence.

Checksums:
CRC64:98B550816D600743
MD5:bb190c481045c21cedc0591f0c172984

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.