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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: H7BY35_HUMAN (H7BY35)

Summary

This is the summary of UniProt entry H7BY35_HUMAN (H7BY35).

Description: Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSP00000353174}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 4950 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam Ins145_P3_rec 1 207
Pfam MIR 210 390
disorder n/a 231 246
disorder n/a 382 391
Pfam RYDR_ITPR 438 632
coiled_coil n/a 456 476
disorder n/a 457 461
Pfam SPRY 656 791
low_complexity n/a 684 702
disorder n/a 693 694
Pfam RyR 846 936
disorder n/a 902 903
disorder n/a 947 948
Pfam RyR 960 1050
disorder n/a 1019 1022
disorder n/a 1055 1057
Pfam SPRY 1084 1204
disorder n/a 1103 1107
low_complexity n/a 1302 1313
disorder n/a 1341 1361
disorder n/a 1385 1389
Pfam SPRY 1409 1544
disorder n/a 1787 1788
disorder n/a 1840 1842
disorder n/a 1845 1855
low_complexity n/a 1856 1875
disorder n/a 1859 1876
disorder n/a 1942 1948
disorder n/a 2028 2039
Pfam RYDR_ITPR 2107 2320
disorder n/a 2338 2363
low_complexity n/a 2354 2364
low_complexity n/a 2400 2410
low_complexity n/a 2481 2494
disorder n/a 2680 2691
Pfam RyR 2685 2775
disorder n/a 2784 2785
disorder n/a 2796 2797
Pfam RyR 2805 2889
coiled_coil n/a 3042 3062
disorder n/a 3059 3065
disorder n/a 3244 3248
coiled_coil n/a 3307 3327
disorder n/a 3426 3431
disorder n/a 3435 3437
disorder n/a 3521 3530
disorder n/a 3630 3642
disorder n/a 3683 3698
low_complexity n/a 3684 3693
low_complexity n/a 3691 3704
disorder n/a 3726 3727
Pfam RIH_assoc 3814 3932
Pfam EF-hand_8 4013 4073
disorder n/a 4197 4210
low_complexity n/a 4202 4211
transmembrane n/a 4217 4243
low_complexity n/a 4236 4264
transmembrane n/a 4264 4283
transmembrane n/a 4289 4306
Pfam RR_TM4-6 4317 4582
disorder n/a 4321 4341
low_complexity n/a 4323 4334
low_complexity n/a 4343 4361
disorder n/a 4386 4391
low_complexity n/a 4426 4441
disorder n/a 4432 4451
transmembrane n/a 4483 4503
transmembrane n/a 4557 4576
Pfam Ion_trans 4690 4861
transmembrane n/a 4693 4714
transmembrane n/a 4720 4739
low_complexity n/a 4749 4767
transmembrane n/a 4751 4772
low_complexity n/a 4826 4844
transmembrane n/a 4827 4850

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession H7BY35. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
DDEVVLQCTA TIHKEQQKLC LAAEGFGNRL CFLESTSNSK NVPPDLSICT
50
51
FVLEQSLSVR ALQEMLANTV EKSEGQVDVE KWLFSLKTAQ GGGHRTLLYG
100
101
HAILLRHSYS GMYLCCLSTS RSSTDKLAFD VGLQEDTTGE ACWWTIHPAS
150
151
KQRSEGEKVR VGDDLILVSV SSERYLHLSY GNGSLHVDAA FQQTLWSVAP
200
201
ISSGSEAAQG YLIGGDVLRL LHGHMDECLT VPSGEHGEEQ RRTVHYEGGA
250
251
VSVHARSLWR LETLRVAWSG SHIRWGQPFR LRHVTTGKYL SLMEDKNLLL
300
301
MDKEKADVKS TAFTFRSSKE KLDVGVRKEV DGMGTSEIKY GDSVCYIQHV
350
351
DTGLWLTYQS VDVKSVRMGS IQRKAIMHHE GHMDDGISLS RSQHEESRTA
400
401
RVIRSTVFLF NRFIRGLDAL SKKAKASTVD LPIESVSLSL QDLIGYFHPP
450
451
DEHLEHEDKQ NRLRALKNRQ NLFQEEGMIN LVLECIDRLH VYSSAAHFAD
500
501
VAGREAGESW KSILNSLYEL LAALIRGNRK NCAQFSGSLD WLISRLERLE
550
551
ASSGILEVLH CVLVESPEAL NIIKEGHIKS IISLLDKHGR NHKVLDVLCS
600
601
LCVCHGVAVR SNQHLICDNL LPGRDLLLQT RLVNHVSSMR PNIFLGVSEG
650
651
SAQYKKWYYE LMVDHTEPFV TAEATHLRVG WASTEGYSPY PGGGEEWGGN
700
701
GVGDDLFSYG FDGLHLWSGC IARTVSSPNQ HLLRTDDVIS CCLDLSAPSI
750
751
SFRINGQPVQ GMFENFNIDG LFFPVVSFSA GIKVRFLLGG RHGEFKFLPP
800
801
PGYAPCYEAV LPKEKLKVEH SREYKQERTY TRDLLGPTVS LTQAAFTPIP
850
851
VDTSQIVLPP HLERIREKLA ENIHELWVMN KIELGWQYGP VRDDNKRQHP
900
901
CLVEFSKLPE QERNYNLQMS LETLKTLLAL GCHVGISDEH AEDKVKKMKL
950
951
PKNYQLTSGY KPAPMDLSFI KLTPSQEAMV DKLAENAHNV WARDRIRQGW
1000
1001
TYGIQQDVKN RRNPRLVPYT LLDDRTKKSN KDSLREAVRT LLGYGYNLEA
1050
1051
PDQDHAARAE VCSGTGERFR IFRAEKTYAV KAGRWYFEFE TVTAGDMRVG
1100
1101
WSRPGCQPDQ ELGSDERAFA FDGFKAQRWH QGNEHYGRSW QAGDVVGCMV
1150
1151
DMNEHTMMFT LNGEILLDDS GSELAFKDFD VGDGFIPVCS LGVAQVGRMN
1200
1201
FGKDVSTLKY FTICGLQEGY EPFAVNTNRD ITMWLSKRLP QFLQVPSNHE
1250
1251
HIEVTRIDGT IDSSPCLKVT QKSFGSQNSN TDIMFYRLSM PIECAEVFSK
1300
1301
TVAGGLPGAG LFGPKNDLED YDADSDFEVL MKTAHGHLVP DRVDKDKEAT
1350
1351
KPEFNNHKDY AQEKPSRLKQ RFLLRRTKPD YSTSHSARLT EDVLADDRDD
1400
1401
YDFLMQTSTY YYSVRIFPGQ EPANVWVGWI TSDFHQYDTG FDLDRVRTVT
1450
1451
VTLGDEKGKV HESIKRSNCY MVCAGESMSP GQGRNNNGLE IGCVVDAASG
1500
1501
LLTFIANGKE LSTYYQVEPS TKLFPAVFAQ ATSPNVFQFE LGRIKNVMPL
1550
1551
SAGLFKSEHK NPVPQCPPRL HVQFLSHVLW SRMPNQFLKV DVSRISERQG
1600
1601
WLVQCLDPLQ FMSLHIPEEN RSVDILELTE QEELLKFHYH TLRLYSAVCA
1650
1651
LGNHRVAHAL CSHVDEPQLL YAIENKYMPG LLRAGYYDLL IDIHLSSYAT
1700
1701
ARLMMNNEYI VPMTEETKSI TLFPDENKKH GLPGIGLSTS LRPRMQFSSP
1750
1751
SFVSISNECY QYSPEFPLDI LKSKTIQMLT EAVKEGSLHA RDPVGGTTEF
1800
1801
LFVPLIKLFY TLLIMGIFHN EDLKHILQLI EPSVFKEAAT PEEESDTLEK
1850
1851
ELSVDDAKLQ GAGEEEAKGG KRPKEGLLQM KLPEPVKLQM CLLLQYLCDC
1900
1901
QVRHRIEAIV AFSDDFVAKL QDNQRFRYNE VMQALNMSAA LTARKTKEFR
1950
1951
SPPQEQINML LNFKDDKSEC PCPEEIRDQL LDFHEDLMTH CGIELDEDGS
2000
2001
LDGNSDLTIR GRLLSLVEKV TYLKKKQAEK PVESDSKKSS TLQQLISETM
2050
2051
VRWAQESVIE DPELVRAMFV LLHRQYDGIG GLVRALPKTY TINGVSVEDT
2100
2101
INLLASLGQI RSLLSVRMGK EEEKLMIRGL GDIMNNKVFY QHPNLMRALG
2150
2151
MHETVMEVMV NVLGGGESKE ITFPKMVANC CRFLCYFCRI SRQNQKAMFD
2200
2201
HLSYLLENSS VGLASPAMRG STPLDVAAAS VMDNNELALA LREPDLEKVV
2250
2251
RYLAGCGLQS CQMLVSKGYP DIGWNPVEGE RYLDFLRFAV FCNGESVEEN
2300
2301
ANVVVRLLIR RPECFGPALR GEGGNGLLAA MEEAIKIAED PSRDGPSPNS
2350
2351
GSSKTLDTEE EEDDTIHMGN AIMTFYSALI DLLGRCAPEM HLIHAGKGEA
2400
2401
IRIRSILRSL IPLGDLVGVI SIAFQMPTIA KDGNVVEPDM SAGFCPDHKA
2450
2451
AMVLFLDRVY GIEVQDFLLH LLEVGFLPDL RAAASLDTAA LSATDMALAL
2500
2501
NRYLCTAVLP LLTRCAPLFA GTEHHASLID SLLHTVYRLS KGCSLTKAQR
2550
2551
DSIEVCLLSI CGQLRPSMMQ HLLRRLVFDV PLLNEHAKMP LKLLTNHYER
2600
2601
CWKYYCLPGG WGNFGAASEE ELHLSRKLFW GIFDALSQKK YEQELFKLAL
2650
2651
PCLSAVAGAL PPDYMESNYV SMMEKQSSMD SEGNFNPQPV DTSNITIPEK
2700
2701
LEYFINKYAE HSHDKWSMDK LANGWIYGEI YSDSSKVQPL MKPYKLLSEK
2750
2751
EKEIYRWPIK ESLKTMLAWG WRIERTREGD SMALYNRTRR ISQTSQVSVD
2800
2801
AAHGYSPRAI DMSNVTLSRD LHAMAEMMAE NYHNIWAKKK KMELESKGGG
2850
2851
NHPLLVPYDT LTAKEKAKDR EKAQDILKFL QINGYAVSRG FKDLELDTPS
2900
2901
IEKRFAYSFL QQLIRYVDEA HQYILEFDGG SRGKGEHFPY EQEIKFFAKV
2950
2951
VLPLIDQYFK NHRLYFLSAA SRPLCSGGHA SNKEKEMVTS LFCKLGVLVR
3000
3001
HRISLFGNDA TSIVNCLHIL GQTLDARTVM KTGLESVKSA LRAFLDNAAE
3050
3051
DLEKTMENLK QGQFTHTRNQ PKGVTQIINY TTVALLPMLS SLFEHIGQHQ
3100
3101
FGEDLILEDV QVSCYRILTS LYALGTSKSI YVERQRSALG ECLAAFAGAF
3150
3151
PVAFLETHLD KHNIYSIYNT KSSRERAALS LPTNVEDVCP NIPSLEKLME
3200
3201
EIVELAESGI RYTQMPHVME VILPMLCSYM SRWWEHGPEN NPERAEMCCT
3250
3251
ALNSEHMNTL LGNILKIIYN NLGIDEGAWM KRLAVFSQPI INKVKPQLLK
3300
3301
THFLPLMEKL KKKAATVVSE EDHLKAEARG DMSEAELLIL DEFTTLARDL
3350
3351
YAFYPLLIRF VDYNRAKWLK EPNPEAEELF RMVAEVFIYW SKSHNFKREE
3400
3401
QNFVVQNEIN NMSFLITDTK SKMSKAAVSD QERKKMKRKG DRYSMQTSLI
3450
3451
VAALKRLLPI GLNICAPGDQ ELIALAKNRF SLKDTEDEVR DIIRSNIHLQ
3500
3501
GKLEDPAIRW QMALYKDLPN RTDDTSDPEK TVERVLDIAN VLFHLEQKSK
3550
3551
RVGRRHYCLV EHPQRSKKAV WHKLLSKQRK RAVVACFRMA PLYNLPRHRA
3600
3601
VNLFLQGYEK SWIETEEHYF EDKLIEDLAK PGAEPPEEDE GTKRVDPLHQ
3650
3651
LILLFSRTAL TEKCKLEEDF LYMAYADIMA KSCHDEEDDD GEEEVKSFEE
3700
3701
KEMEKQKLLY QQARLHDRGA AEMVLQTISA SKGETGPMVA ATLKLGIAIL
3750
3751
NGGNSTVQQK MLDYLKEKKD VGFFQSLAGL MQSCSVLDLN AFERQNKAEG
3800
3801
LGMVTEEGSG EKVLQDDEFT CDLFRFLQLL CEGHNSDFQN YLRTQTGNNT
3850
3851
TVNIIISTVD YLLRVQESIS DFYWYYSGKD VIDEQGQRNF SKAIQVAKQV
3900
3901
FNTLTEYIQG PCTGNQQSLA HSRLWDAVVG FLHVFAHMQM KLSQDSSQIE
3950
3951
LLKELMDLQK DMVVMLLSML EGNVVNGTIG KQMVDMLVES SNNVEMILKF
4000
4001
FDMFLKLKDL TSSDTFKEYD PDGKGVISKR DFHKAMESHK HYTQSETEFL
4050
4051
LSCAETDENE TLDYEEFVKR FHEPAKDIGF NVAVLLTNLS EHMPNDTRLQ
4100
4101
TFLELAESVL NYFQPFLGRI EIMGSAKRIE RVYFEISESS RTQWEKPQVK
4150
4151
ESKRQFIFDV VNEGGEKEKM ELFVNFCEDT IFEMQLAAQI SESDLNERSA
4200
4201
NKEESEKERP EEQGPRMAFF SILTVRSALF ALRYNILTLM RMLSLKSLKK
4250
4251
QMKKVKKMTV KDMVTAFFSS YWSIFMTLLH FVASVFRGFF RIICSLLLGG
4300
4301
SLVEGAKKIK VAELLANMPD PTQDEVRGDG EEGERKPLEA ALPSEDLTDL
4350
4351
KELTEESDLL SDIFGLDLKR EGGQYKLIPH NPNAGLSDLM SNPVPMPEVQ
4400
4401
EKFQVIYLVT AAFSRRAYVL FVCFHRGEDG EKEEKAKEDK GKQKLRQLHT
4450
4451
HRYGEPEVPE SAFWKKIIAY QQKLLNYFAR NFYNMRMLAL FVAFAINFIL
4500
4501
LFYKVSTSSV VEGKELPTRS SSENAKVTSL DSSSHRIIAV HYVLEESSGY
4550
4551
MEPTLRILAI LHTVISFFCI IGYYCLKVPL VIFKREKEVA RKLEFDGLYI
4600
4601
TEQPSEDDIK GQWDRLVINT QSFPNNYWDK FVKRKVMDKY GEFYGRDRIS
4650
4651
ELLGMDKAAL DFSDAREKKK PKKDSSLSAV LNSIDVKYQM WKLGVVFTDN
4700
4701
SFLYLAWYMT MSVLGHYNNF FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL
4750
4751
VLTVGLLAVV VYLYTVVAFN FFRKFYNKSE DGDTPDMKCD DMLTCYMFHM
4800
4801
YVGVRAGGGI GDEIEDPAGD EYEIYRIIFD ITFFFFVIVI LLAIIQGLII
4850
4851
DAFGELRDQQ EQVKEDMETK CFICGIGNDY FDTVPHGFET HTLQEHNLAN
4900
4901
YLFFLMYLIN KDETEHTGQE SYVWKMYQER CWEFFPAGDC FRKQYEDQLN
4950
4951
                                                      
4950
 

Show the unformatted sequence.

Checksums:
CRC64:1847F6C7A58F01CF
MD5:1d9cbef89c8b7f5fd75d196a9d2119b8