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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MASP2_HUMAN (O00187)

Summary

This is the summary of UniProt entry MASP2_HUMAN (O00187).

Description: Mannan-binding lectin serine protease 2 EC=3.4.21.104
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 686 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 15
low_complexity n/a 2 9
Pfam CUB 24 134
Pfam EGF_CA 138 180
Pfam CUB 184 293
disorder n/a 195 196
Pfam Sushi 300 361
Pfam Sushi 366 430
Pfam Trypsin 445 679

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O00187. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRLLTLLGLL CGSVATPLGP KWPEPVFGRL ASPGFPGEYA NDQERRWTLT
50
51
APPGYRLRLY FTHFDLELSH LCEYDFVKLS SGAKVLATLC GQESTDTERA
100
101
PGKDTFYSLG SSLDITFRSD YSNEKPFTGF EAFYAAEDID ECQVAPGEAP
150
151
TCDHHCHNHL GGFYCSCRAG YVLHRNKRTC SALCSGQVFT QRSGELSSPE
200
201
YPRPYPKLSS CTYSISLEEG FSVILDFVES FDVETHPETL CPYDFLKIQT
250
251
DREEHGPFCG KTLPHRIETK SNTVTITFVT DESGDHTGWK IHYTSTAQPC
300
301
PYPMAPPNGH VSPVQAKYIL KDSFSIFCET GYELLQGHLP LKSFTAVCQK
350
351
DGSWDRPMPA CSIVDCGPPD DLPSGRVEYI TGPGVTTYKA VIQYSCEETF
400
401
YTMKVNDGKY VCEADGFWTS SKGEKSLPVC EPVCGLSART TGGRIYGGQK
450
451
AKPGDFPWQV LILGGTTAAG ALLYDNWVLT AAHAVYEQKH DASALDIRMG
500
501
TLKRLSPHYT QAWSEAVFIH EGYTHDAGFD NDIALIKLNN KVVINSNITP
550
551
ICLPRKEAES FMRTDDIGTA SGWGLTQRGF LARNLMYVDI PIVDHQKCTA
600
601
AYEKPPYPRG SVTANMLCAG LESGGKDSCR GDSGGALVFL DSETERWFVG
650
651
GIVSWGSMNC GEAGQYGVYT KVINYIPWIE NIISDF               
686
 

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Checksums:
CRC64:ED952085FA115E21
MD5:44453fdad3b72140d79d9d471ee2e3b2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CUB 24 - 134 1SZB A 9 - 119 Jmol OpenAstexViewer
B 9 - 119 Jmol OpenAstexViewer
EGF_CA 138 - 180 1SZB A 123 - 165 Jmol OpenAstexViewer
B 123 - 165 Jmol OpenAstexViewer
Sushi 300 - 361 1ZJK A 300 - 361 Jmol OpenAstexViewer
4FXG G 300 - 361 Jmol OpenAstexViewer
I 300 - 361 Jmol OpenAstexViewer
5JPM G 300 - 361 Jmol OpenAstexViewer
I 300 - 361 Jmol OpenAstexViewer
366 - 430 1Q3X A 366 - 430 Jmol OpenAstexViewer
B 366 - 430 Jmol OpenAstexViewer
1ZJK A 366 - 430 Jmol OpenAstexViewer
3TVJ A 366 - 430 Jmol OpenAstexViewer
4FXG G 366 - 430 Jmol OpenAstexViewer
I 366 - 430 Jmol OpenAstexViewer
5JPM G 366 - 430 Jmol OpenAstexViewer
I 366 - 430 Jmol OpenAstexViewer
Trypsin 445 - 679 1Q3X A 445 - 679 Jmol OpenAstexViewer
B 445 - 679 Jmol OpenAstexViewer
1ZJK A 445 - 679 Jmol OpenAstexViewer
3TVJ B 445 - 679 Jmol OpenAstexViewer
4FXG H 445 - 679 Jmol OpenAstexViewer
J 445 - 679 Jmol OpenAstexViewer
5JPM H 445 - 679 Jmol OpenAstexViewer
J 445 - 679 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.