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10  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TLR4_HUMAN (O00206)

Summary

This is the summary of UniProt entry TLR4_HUMAN (O00206).

Description: Toll-like receptor 4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 839 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 23
Pfam LRR_8 55 114
Pfam LRR_8 78 138
low_complexity n/a 115 127
Pfam LRR_8 134 187
Pfam LRR_8 150 207
low_complexity n/a 202 212
low_complexity n/a 291 302
Pfam LRR_8 447 508
Pfam LRR_8 485 532
Pfam LRR_8 496 556
transmembrane n/a 633 652
low_complexity n/a 635 650
Pfam TIR 674 839

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O00206. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MMSASRLAGT LIPAMAFLSC VRPESWEPCV EVVPNITYQC MELNFYKIPD
50
51
NLPFSTKNLD LSFNPLRHLG SYSFFSFPEL QVLDLSRCEI QTIEDGAYQS
100
101
LSHLSTLILT GNPIQSLALG AFSGLSSLQK LVAVETNLAS LENFPIGHLK
150
151
TLKELNVAHN LIQSFKLPEY FSNLTNLEHL DLSSNKIQSI YCTDLRVLHQ
200
201
MPLLNLSLDL SLNPMNFIQP GAFKEIRLHK LTLRNNFDSL NVMKTCIQGL
250
251
AGLEVHRLVL GEFRNEGNLE KFDKSALEGL CNLTIEEFRL AYLDYYLDDI
300
301
IDLFNCLTNV SSFSLVSVTI ERVKDFSYNF GWQHLELVNC KFGQFPTLKL
350
351
KSLKRLTFTS NKGGNAFSEV DLPSLEFLDL SRNGLSFKGC CSQSDFGTTS
400
401
LKYLDLSFNG VITMSSNFLG LEQLEHLDFQ HSNLKQMSEF SVFLSLRNLI
450
451
YLDISHTHTR VAFNGIFNGL SSLEVLKMAG NSFQENFLPD IFTELRNLTF
500
501
LDLSQCQLEQ LSPTAFNSLS SLQVLNMSHN NFFSLDTFPY KCLNSLQVLD
550
551
YSLNHIMTSK KQELQHFPSS LAFLNLTQND FACTCEHQSF LQWIKDQRQL
600
601
LVEVERMECA TPSDKQGMPV LSLNITCQMN KTIIGVSVLS VLVVSVVAVL
650
651
VYKFYFHLML LAGCIKYGRG ENIYDAFVIY SSQDEDWVRN ELVKNLEEGV
700
701
PPFQLCLHYR DFIPGVAIAA NIIHEGFHKS RKVIVVVSQH FIQSRWCIFE
750
751
YEIAQTWQFL SSRAGIIFIV LQKVEKTLLR QQVELYRLLS RNTYLEWEDS
800
801
VLGRHIFWRR LRKALLDGKS WNPEGTVGTG CNWQEATSI            
839
 

Show the unformatted sequence.

Checksums:
CRC64:92C48F55821133E8
MD5:70505bff44a5752121f6174e6eeabca2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
LRR_8 134 - 187 2Z62 A 134 - 187 Jmol OpenAstexViewer
2Z63 A 134 - 187 Jmol OpenAstexViewer
2Z65 A 134 - 187 Jmol OpenAstexViewer
B 134 - 187 Jmol OpenAstexViewer
3FXI A 134 - 187 Jmol OpenAstexViewer
B 134 - 187 Jmol OpenAstexViewer
3UL7 A 134 - 187 Jmol OpenAstexViewer
3UL8 A 134 - 187 Jmol OpenAstexViewer
3UL9 A 134 - 187 Jmol OpenAstexViewer
3ULA A 134 - 187 Jmol OpenAstexViewer
C 134 - 187 Jmol OpenAstexViewer
4G8A A 134 - 187 Jmol OpenAstexViewer
B 134 - 187 Jmol OpenAstexViewer
150 - 207 2Z62 A 150 - 207 Jmol OpenAstexViewer
2Z63 A 150 - 207 Jmol OpenAstexViewer
2Z65 A 150 - 207 Jmol OpenAstexViewer
B 150 - 207 Jmol OpenAstexViewer
3FXI A 150 - 207 Jmol OpenAstexViewer
B 150 - 207 Jmol OpenAstexViewer
3UL7 A 150 - 207 Jmol OpenAstexViewer
3UL8 A 150 - 207 Jmol OpenAstexViewer
3UL9 A 150 - 207 Jmol OpenAstexViewer
3ULA A 150 - 207 Jmol OpenAstexViewer
C 150 - 207 Jmol OpenAstexViewer
4G8A A 150 - 207 Jmol OpenAstexViewer
B 150 - 207 Jmol OpenAstexViewer
447 - 508 2Z63 A 447 - 508 Jmol OpenAstexViewer
2Z66 A 447 - 508 Jmol OpenAstexViewer
B 447 - 508 Jmol OpenAstexViewer
C 447 - 508 Jmol OpenAstexViewer
D 447 - 508 Jmol OpenAstexViewer
3FXI A 447 - 508 Jmol OpenAstexViewer
B 447 - 508 Jmol OpenAstexViewer
4G8A A 447 - 508 Jmol OpenAstexViewer
B 447 - 508 Jmol OpenAstexViewer
485 - 527 2Z63 A 485 - 527 Jmol OpenAstexViewer
485 - 532 2Z66 A 485 - 532 Jmol OpenAstexViewer
B 485 - 532 Jmol OpenAstexViewer
C 485 - 532 Jmol OpenAstexViewer
D 485 - 532 Jmol OpenAstexViewer
3FXI A 485 - 532 Jmol OpenAstexViewer
B 485 - 532 Jmol OpenAstexViewer
4G8A A 485 - 532 Jmol OpenAstexViewer
B 485 - 532 Jmol OpenAstexViewer
496 - 527 2Z63 A 496 - 527 Jmol OpenAstexViewer
496 - 556 2Z66 A 496 - 556 Jmol OpenAstexViewer
B 496 - 556 Jmol OpenAstexViewer
C 496 - 556 Jmol OpenAstexViewer
D 496 - 556 Jmol OpenAstexViewer
3FXI A 496 - 556 Jmol OpenAstexViewer
B 496 - 556 Jmol OpenAstexViewer
4G8A A 496 - 556 Jmol OpenAstexViewer
B 496 - 556 Jmol OpenAstexViewer
55 - 114 2Z62 A 55 - 114 Jmol OpenAstexViewer
2Z63 A 55 - 114 Jmol OpenAstexViewer
2Z65 A 55 - 114 Jmol OpenAstexViewer
B 55 - 114 Jmol OpenAstexViewer
3FXI A 55 - 114 Jmol OpenAstexViewer
B 55 - 114 Jmol OpenAstexViewer
3UL7 A 55 - 114 Jmol OpenAstexViewer
3UL8 A 55 - 114 Jmol OpenAstexViewer
3UL9 A 55 - 114 Jmol OpenAstexViewer
3ULA A 55 - 114 Jmol OpenAstexViewer
C 55 - 114 Jmol OpenAstexViewer
4G8A A 55 - 114 Jmol OpenAstexViewer
B 55 - 114 Jmol OpenAstexViewer
78 - 138 2Z62 A 78 - 138 Jmol OpenAstexViewer
2Z63 A 78 - 138 Jmol OpenAstexViewer
2Z65 A 78 - 138 Jmol OpenAstexViewer
B 78 - 138 Jmol OpenAstexViewer
3FXI A 78 - 138 Jmol OpenAstexViewer
B 78 - 138 Jmol OpenAstexViewer
3UL7 A 78 - 138 Jmol OpenAstexViewer
3UL8 A 78 - 138 Jmol OpenAstexViewer
3UL9 A 78 - 138 Jmol OpenAstexViewer
3ULA A 78 - 138 Jmol OpenAstexViewer
C 78 - 138 Jmol OpenAstexViewer
4G8A A 78 - 138 Jmol OpenAstexViewer
B 78 - 138 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.