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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: PGRC1_HUMAN (O00264)

Summary

This is the summary of UniProt entry PGRC1_HUMAN (O00264).

Description: Membrane-associated progesterone receptor component 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 195 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 8 9
transmembrane n/a 25 43
low_complexity n/a 29 41
disorder n/a 52 71
Pfam Cyt-b5 74 171
coiled_coil n/a 132 152
disorder n/a 140 144
disorder n/a 146 148
disorder n/a 174 195

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O00264. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAEDVVATG ADPSDLESGG LLHEIFTSPL NLLLLGLCIF LLYKIVRGDQ
50
51
PAASGDSDDD EPPPLPRLKR RDFTPAELRR FDGVQDPRIL MAINGKVFDV
100
101
TKGRKFYGPE GPYGVFAGRD ASRGLATFCL DKEALKDEYD DLSDLTAAQQ
150
151
ETLSDWESQF TFKYHHVGKL LKEGEEPTVY SDEEEPKDES ARKND     
195
 

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Checksums:
CRC64:CCD5E802E1C9E604
MD5:4472d248cc45ed05c8cf00d31fc06471

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Cyt-b5 74 - 171 4X8Y A 74 - 171 Jmol OpenAstexViewer
B 74 - 171 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.