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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SPT5H_HUMAN (O00267)

Summary

This is the summary of UniProt entry SPT5H_HUMAN (O00267).

Description: Transcription elongation factor SPT5
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1087 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 117
low_complexity n/a 2 25
low_complexity n/a 37 64
coiled_coil n/a 40 63
Pfam Spt5_N 75 172
low_complexity n/a 78 94
disorder n/a 124 128
disorder n/a 156 159
disorder n/a 161 162
disorder n/a 166 168
Pfam Spt5-NGN 178 264
disorder n/a 406 408
disorder n/a 414 422
Pfam KOW 474 505
disorder n/a 656 661
disorder n/a 664 709
low_complexity n/a 678 701
disorder n/a 721 724
disorder n/a 731 981
low_complexity n/a 832 843
low_complexity n/a 896 911
disorder n/a 983 985
disorder n/a 1026 1031
disorder n/a 1036 1042

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O00267. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSDSEDSNFS EEEDSERSSD GEEAEVDEER RSAAGSEKEE EPEDEEEEEE
50
51
EEEYDEEEEE EDDDRPPKKP RHGGFILDEA DVDDEYEDED QWEDGAEDIL
100
101
EKEEIEASNI DNVVLDEDRS GARRLQNLWR DQREEELGEY YMKKYAKSSV
150
151
GETVYGGSDE LSDDITQQQL LPGVKDPNLW TVKCKIGEER ATAISLMRKF
200
201
IAYQFTDTPL QIKSVVAPEH VKGYIYVEAY KQTHVKQAIE GVGNLRLGYW
250
251
NQQMVPIKEM TDVLKVVKEV ANLKPKSWVR LKRGIYKDDI AQVDYVEPSQ
300
301
NTISLKMIPR IDYDRIKARM SLKDWFAKRK KFKRPPQRLF DAEKIRSLGG
350
351
DVASDGDFLI FEGNRYSRKG FLFKSFAMSA VITEGVKPTL SELEKFEDQP
400
401
EGIDLEVVTE STGKEREHNF QPGDNVEVCE GELINLQGKI LSVDGNKITI
450
451
MPKHEDLKDM LEFPAQELRK YFKMGDHVKV IAGRFEGDTG LIVRVEENFV
500
501
ILFSDLTMHE LKVLPRDLQL CSETASGVDV GGQHEWGELV QLDPQTVGVI
550
551
VRLERETFQV LNMYGKVVTV RHQAVTRKKD NRFAVALDSE QNNIHVKDIV
600
601
KVIDGPHSGR EGEIRHLFRS FAFLHCKKLV ENGGMFVCKT RHLVLAGGSK
650
651
PRDVTNFTVG GFAPMSPRIS SPMHPSAGGQ RGGFGSPGGG SGGMSRGRGR
700
701
RDNELIGQTV RISQGPYKGY IGVVKDATES TARVELHSTC QTISVDRQRL
750
751
TTVGSRRPGG MTSTYGRTPM YGSQTPMYGS GSRTPMYGSQ TPLQDGSRTP
800
801
HYGSQTPLHD GSRTPAQSGA WDPNNPNTPS RAEEEYEYAF DDEPTPSPQA
850
851
YGGTPNPQTP GYPDPSSPQV NPQYNPQTPG TPAMYNTDQF SPYAAPSPQG
900
901
SYQPSPSPQS YHQVAPSPAG YQNTHSPASY HPTPSPMAYQ ASPSPSPVGY
950
951
SPMTPGAPSP GGYNPHTPGS GIEQNSSDWV TTDIQVKVRD TYLDTQVVGQ
1000
1001
TGVIRSVTGG MCSVYLKDSE KVVSISSEHL EPITPTKNNK VKVILGEDRE
1050
1051
ATGVLLSIDG EDGIVRMDLD EQLKILNLRF LGKLLEA              
1087
 

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Checksums:
CRC64:EC3F402A670A5B7D
MD5:df9972e09b572a6b96b753aa923cfcd2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
KOW 474 - 505 2DO3 A 474 - 505 Show 3D Structure View in InterPro
5OIK Z 474 - 505 Show 3D Structure View in InterPro
6GMH Z 474 - 505 Show 3D Structure View in InterPro
6GML Z 474 - 505 Show 3D Structure View in InterPro
6TED Z 474 - 505 Show 3D Structure View in InterPro
Spt5-NGN 178 - 264 3H7H B 178 - 264 Show 3D Structure View in InterPro
5OIK Z 178 - 264 Show 3D Structure View in InterPro
6GMH Z 178 - 264 Show 3D Structure View in InterPro
6GML Z 178 - 264 Show 3D Structure View in InterPro
6TED Z 178 - 264 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;