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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DFFA_HUMAN (O00273)

Summary

This is the summary of UniProt entry DFFA_HUMAN (O00273).

Description: DNA fragmentation factor subunit alpha
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 331 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 6
Pfam CIDE-N 18 95
Pfam DFF-C 100 264
low_complexity n/a 132 145
coiled_coil n/a 168 202
disorder n/a 219 221
disorder n/a 256 261
disorder n/a 290 291
disorder n/a 306 331

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O00273. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEVTGDAGVP ESGEIRTLKP CLLRRNYSRE QHGVAASCLE DLRSKACDIL
50
51
AIDKSLTPVT LVLAEDGTIV DDDDYFLCLP SNTKFVALAS NEKWAYNNSD
100
101
GGTAWISQES FDVDETDSGA GLKWKNVARQ LKEDLSSIIL LSEEDLQMLV
150
151
DAPCSDLAQE LRQSCATVQR LQHTLQQVLD QREEVRQSKQ LLQLYLQALE
200
201
KEGSLLSKQE ESKAAFGEEV DAVDTGISRE TSSDVALASH ILTALREKQA
250
251
PELSLSSQDL ELVTKEDPKA LAVALNWDIK KTETVQEACE RELALRLQQT
300
301
QSLHSLRSIS ASKASPPGDL QNPKRARQDP T                    
331
 

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Checksums:
CRC64:8656FE45DB003DF3
MD5:367e42dc7da613b6bf66313bac94ef1d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CIDE-N 18 - 95 1IBX B 18 - 95 Jmol OpenAstexViewer
DFF-C 225 - 264 1IYR A 5 - 44 Jmol OpenAstexViewer
239 - 264 1KOY A 239 - 264 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.