Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PLK4_HUMAN (O00444)

Summary

This is the summary of UniProt entry PLK4_HUMAN (O00444).

Description: Serine/threonine-protein kinase PLK4 EC=2.7.11.21
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 970 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam Pkinase 12 265
disorder n/a 270 273
disorder n/a 275 281
low_complexity n/a 287 302
disorder n/a 318 332
disorder n/a 335 432
disorder n/a 434 483
disorder n/a 490 544
disorder n/a 547 549
disorder n/a 560 563
disorder n/a 566 583
disorder n/a 660 663
disorder n/a 670 671
disorder n/a 809 830
disorder n/a 833 839
disorder n/a 845 851
disorder n/a 853 855
disorder n/a 862 865
disorder n/a 867 868
disorder n/a 874 875
Pfam POLO_box 894 955
disorder n/a 930 932
disorder n/a 934 941

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O00444. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK
50
51
AGMVQRVQNE VKIHCQLKHP SILELYNYFE DSNYVYLVLE MCHNGEMNRY
100
101
LKNRVKPFSE NEARHFMHQI ITGMLYLHSH GILHRDLTLS NLLLTRNMNI
150
151
KIADFGLATQ LKMPHEKHYT LCGTPNYISP EIATRSAHGL ESDVWSLGCM
200
201
FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PSFLSIEAKD LIHQLLRRNP
250
251
ADRLSLSSVL DHPFMSRNSS TKSKDLGTVE DSIDSGHATI STAITASSST
300
301
SISGSLFDKR RLLIGQPLPN KMTVFPKNKS STDFSSSGDG NSFYTQWGNQ
350
351
ETSNSGRGRV IQDAEERPHS RYLRRAYSSD RSGTSNSQSQ AKTYTMERCH
400
401
SAEMLSVSKR SGGGENEERY SPTDNNANIF NFFKEKTSSS SGSFERPDNN
450
451
QALSNHLCPG KTPFPFADPT PQTETVQQWF GNLQINAHLR KTTEYDSISP
500
501
NRDFQGHPDL QKDTSKNAWT DTKVKKNSDA SDNAHSVKQQ NTMKYMTALH
550
551
SKPEIIQQEC VFGSDPLSEQ SKTRGMEPPW GYQNRTLRSI TSPLVAHRLK
600
601
PIRQKTKKAV VSILDSEEVC VELVKEYASQ EYVKEVLQIS SDGNTITIYY
650
651
PNGGRGFPLA DRPPSPTDNI SRYSFDNLPE KYWRKYQYAS RFVQLVRSKS
700
701
PKITYFTRYA KCILMENSPG ADFEVWFYDG VKIHKTEDFI QVIEKTGKSY
750
751
TLKSESEVNS LKEEIKMYMD HANEGHRICL ALESIISEEE RKTRSAPFFP
800
801
IIIGRKPGST SSPKALSPPP SVDSNYPTRE RASFNRMVMH SAASPTQAPI
850
851
LNPSMVTNEG LGLTTTASGT DISSNSLKDC LPKSAQLLKS VFVKNVGWAT
900
901
QLTSGAVWVQ FNDGSQLVVQ AGVSSISYTS PNGQTTRYGE NEKLPDYIKQ
950
951
KLQCLSSILL MFSNPTPNFH                                 
970
 

Show the unformatted sequence.

Checksums:
CRC64:4D56F5FD983211A6
MD5:2b7018a774a883c2c7404de9d40e9a42

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 12 - 265 3COK A 11 - 264 Jmol OpenAstexViewer
B 11 - 264 Jmol OpenAstexViewer
4JXF A 12 - 265 Jmol OpenAstexViewer
4YUR A 12 - 265 Jmol OpenAstexViewer
POLO_box 894 - 955 2N19 A 894 - 955 Jmol OpenAstexViewer
4YYP A 894 - 955 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.