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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ELL2_HUMAN (O00472)

Summary

This is the summary of UniProt entry ELL2_HUMAN (O00472).

Description: RNA polymerase II elongation factor ELL2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 640 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 5
Pfam ELL 11 291
disorder n/a 96 97
disorder n/a 99 100
disorder n/a 132 157
disorder n/a 159 160
disorder n/a 164 165
disorder n/a 167 168
disorder n/a 170 201
disorder n/a 226 232
disorder n/a 236 244
disorder n/a 283 315
disorder n/a 318 327
disorder n/a 334 517
low_complexity n/a 359 378
low_complexity n/a 454 477
low_complexity n/a 474 495
coiled_coil n/a 480 500
Pfam Occludin_ELL 532 633
disorder n/a 580 585
disorder n/a 597 600

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O00472. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAGGTGGLR EEQRYGLSCG RLGQDNITVL HVKLTETAIR ALETYQSHKN
50
51
LIPFRPSIQF QGLHGLVKIP KNDPLNEVHN FNFYLSNVGK DNPQGSFDCI
100
101
QQTFSSSGAS QLNCLGFIQD KITVCATNDS YQMTRERMTQ AEEESRNRST
150
151
KVIKPGGPYV GKRVQIRKAP QAVSDTVPER KRSTPMNPAN TIRKTHSSST
200
201
ISQRPYRDRV IHLLALKAYK KPELLARLQK DGVNQKDKNS LGAILQQVAN
250
251
LNSKDLSYTL KDYVFKELQR DWPGYSEIDR RSLESVLSRK LNPSQNAAGT
300
301
SRSESPVCSS RDAVSSPQKR LLDSEFIDPL MNKKARISHL TNRVPPTLNG
350
351
HLNPTSEKSA AGLPLPPAAA AIPTPPPLPS TYLPISHPPQ IVNSNSNSPS
400
401
TPEGRGTQDL PVDSFSQNDS IYEDQQDKYT SRTSLETLPP GSVLLKCPKP
450
451
MEENHSMSHK KSKKKSKKHK EKDQIKKHDI ETIEEKEEDL KREEEIAKLN
500
501
NSSPNSSGGV KEDCTASMEP SAIELPDYLI KYIAIVSYEQ RQNYKDDFNA
550
551
EYDEYRALHA RMETVARRFI KLDAQRKRLS PGSKEYQNVH EEVLQEYQKI
600
601
KQSSPNYHEE KYRCEYLHNK LAHIKRLIGE FDQQQAESWS           
640
 

Show the unformatted sequence.

Checksums:
CRC64:96D6228AF868E6C9
MD5:46dc12a89719e202abd0b473fa15382e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ELL 200 - 291 2E5N A 8 - 99 Jmol OpenAstexViewer
Occludin_ELL 532 - 633 5JW9 B 532 - 633 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.