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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HTRA1_MYCTU (O06291)

Summary

This is the summary of UniProt entry HTRA1_MYCTU (O06291).

Description: Probable serine protease HtrA1 {ECO:0000305}
Source organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (NCBI taxonomy ID 83332)
Length: 528 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 98
low_complexity n/a 30 39
disorder n/a 102 103
disorder n/a 107 108
disorder n/a 112 113
disorder n/a 115 147
low_complexity n/a 129 144
low_complexity n/a 139 161
transmembrane n/a 178 198
low_complexity n/a 179 199
disorder n/a 216 217
disorder n/a 220 221
Pfam Trypsin_2 254 401
disorder n/a 293 295
disorder n/a 359 360
disorder n/a 367 369
disorder n/a 373 379
Pfam PDZ_2 440 522
disorder n/a 513 528

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O06291. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDTRVDTDNA MPARFSAQIQ NEDEVTSDQG NNGGPNGGGR LAPRPVFRPP
50
51
VDPASRQAFG RPSGVQGSFV AERVRPQKYQ DQSDFTPNDQ LADPVLQEAF
100
101
GRPFAGAESL QRHPIDAGAL AAEKDGAGPD EPDDPWRDPA AAAALGTPAL
150
151
AAPAPHGALA GSGKLGVRDV LFGGKVSYLA LGILVAIALV IGGIGGVIGR
200
201
KTAEVVDAFT TSKVTLSTTG NAQEPAGRFT KVAAAVADSV VTIESVSDQE
250
251
GMQGSGVIVD GRGYIVTNNH VISEAANNPS QFKTTVVFND GKEVPANLVG
300
301
RDPKTDLAVL KVDNVDNLTV ARLGDSSKVR VGDEVLAVGA PLGLRSTVTQ
350
351
GIVSALHRPV PLSGEGSDTD TVIDAIQTDA SINHGNSGGP LIDMDAQVIG
400
401
INTAGKSLSD SASGLGFAIP VNEMKLVANS LIKDGKIVHP TLGISTRSVS
450
451
NAIASGAQVA NVKAGSPAQK GGILENDVIV KVGNRAVADS DEFVVAVRQL
500
501
AIGQDAPIEV VREGRHVTLT VKPDPDST                        
528
 

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Checksums:
CRC64:F9C4C6FD6C87BCB3
MD5:71f173d81631bfda8436e1e1368a83a7

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PDZ_2 440 - 522 5ZVJ A 440 - 522 Show 3D Structure View in InterPro
6IEO A 440 - 522 Show 3D Structure View in InterPro
Trypsin_2 254 - 401 5ZVJ A 254 - 401 Show 3D Structure View in InterPro
6IEO A 254 - 401 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;