Homo sapiens (Human)
(NCBI taxonomy ID
|Length:||391 amino acids|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
This image shows the arrangement of the Pfam domains that we found on this sequence. Clicking on a domain will take you to the page describing that Pfam entry. The table below gives the domain boundaries for each of the domains. More...
E-values are based on searching the Pfam-A family against UniProtKB 2020_06 using hmmsearch.
Download the data used to generate the domain graphic in JSON format.
or the data used to generate the graphic in JSON format.
|Source||Domain||Start||End||Gathering threshold (bits)||Score (bits)||E-value|
or domain scores.
This is the amino acid sequence of the UniProt sequence database entry with the accession O14717. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
MEPLRVLELY SGVGGMHHAL RESCIPAQVV AAIDVNTVAN EVYKYNFPHT
QLLAKTIEGI TLEEFDRLSF DMILMSPPCQ PFTRIGRQGD MTDSRTNSFL
HILDILPRLQ KLPKYILLEN VKGFEVSSTR DLLIQTIENC GFQYQEFLLS
PTSLGIPNSR LRYFLIAKLQ SEPLPFQAPG QVLMEFPKIE SVHPQKYAMD
VENKIQEKNV EPNISFDGSI QCSGKDAILF KLETAEEIHR KNQQDSDLSV
KMLKDFLEDD TDVNQYLLPP KSLLRYALLL DIVQPTCRRS VCFTKGYGSY
IEGTGSVLQT AEDVQVENIY KSLTNLSQEE QITKLLILKL RYFTPKEIAN
LLGFPPEFGF PEKITVKQRY RLLGNSLNVH VVAKLIKILY E
the unformatted sequence.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
|Pfam family||UniProt residues||PDB ID||PDB chain ID||PDB residues||View|
|DNA_methylase||4 - 391||1G55||A||4 - 391||NGL View in InterPro|
The parts of the structure corresponding to the Pfam family are highlighted in yellow.
Loading Structure Data
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.