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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: TRDMT_HUMAN (O14717)

Summary

This is the summary of UniProt entry TRDMT_HUMAN (O14717).

Description: tRNA (cytosine(38)-C(5))-methyltransferase
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 391 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam DNA_methylase 4 391
disorder n/a 85 87

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O14717. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEPLRVLELY SGVGGMHHAL RESCIPAQVV AAIDVNTVAN EVYKYNFPHT
50
51
QLLAKTIEGI TLEEFDRLSF DMILMSPPCQ PFTRIGRQGD MTDSRTNSFL
100
101
HILDILPRLQ KLPKYILLEN VKGFEVSSTR DLLIQTIENC GFQYQEFLLS
150
151
PTSLGIPNSR LRYFLIAKLQ SEPLPFQAPG QVLMEFPKIE SVHPQKYAMD
200
201
VENKIQEKNV EPNISFDGSI QCSGKDAILF KLETAEEIHR KNQQDSDLSV
250
251
KMLKDFLEDD TDVNQYLLPP KSLLRYALLL DIVQPTCRRS VCFTKGYGSY
300
301
IEGTGSVLQT AEDVQVENIY KSLTNLSQEE QITKLLILKL RYFTPKEIAN
350
351
LLGFPPEFGF PEKITVKQRY RLLGNSLNVH VVAKLIKILY E         
391
 

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Checksums:
CRC64:BCA549E4EB2E6950
MD5:465834e676b4e06e6322c8dd9e203b50

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DNA_methylase 4 - 391 1G55 A 4 - 391 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.