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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NDC80_HUMAN (O14777)

Summary

This is the summary of UniProt entry NDC80_HUMAN (O14777).

Description: Kinetochore protein NDC80 homolog
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 642 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 33
disorder n/a 37 44
Pfam Ndc80_HEC 51 206
disorder n/a 54 61
disorder n/a 72 74
disorder n/a 205 207
Pfam DUF5595 213 285
coiled_coil n/a 265 299
disorder n/a 279 287
disorder n/a 290 291
disorder n/a 293 295
coiled_coil n/a 314 355
coiled_coil n/a 366 400
disorder n/a 367 368
disorder n/a 379 382
coiled_coil n/a 458 538
disorder n/a 473 474
disorder n/a 476 477
disorder n/a 514 516
low_complexity n/a 519 534
disorder n/a 525 534
low_complexity n/a 530 544
disorder n/a 540 541
disorder n/a 543 548
coiled_coil n/a 550 570
disorder n/a 552 554
disorder n/a 564 565
disorder n/a 570 571
disorder n/a 579 581
coiled_coil n/a 597 617
disorder n/a 601 602
disorder n/a 637 638
disorder n/a 641 642

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O14777. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKRSSVSSGG AGRLSMQELR SQDVNKQGLY TPQTKEKPTF GKLSINKPTS
50
51
ERKVSLFGKR TSGHGSRNSQ LGIFSSSEKI KDPRPLNDKA FIQQCIRQLC
100
101
EFLTENGYAH NVSMKSLQAP SVKDFLKIFT FLYGFLCPSY ELPDTKFEEE
150
151
VPRIFKDLGY PFALSKSSMY TVGAPHTWPH IVAALVWLID CIKIHTAMKE
200
201
SSPLFDDGQP WGEETEDGIM HNKLFLDYTI KCYESFMSGA DSFDEMNAEL
250
251
QSKLKDLFNV DAFKLESLEA KNRALNEQIA RLEQEREKEP NRLESLRKLK
300
301
ASLQGDVQKY QAYMSNLESH SAILDQKLNG LNEEIARVEL ECETIKQENT
350
351
RLQNIIDNQK YSVADIERIN HERNELQQTI NKLTKDLEAE QQKLWNEELK
400
401
YARGKEAIET QLAEYHKLAR KLKLIPKGAE NSKGYDFEIK FNPEAGANCL
450
451
VKYRAQVYVP LKELLNETEE EINKALNKKM GLEDTLEQLN AMITESKRSV
500
501
RTLKEEVQKL DDLYQQKIKE AEEEDEKCAS ELESLEKHKH LLESTVNQGL
550
551
SEAMNELDAV QREYQLVVQT TTEERRKVGN NLQRLLEMVA THVGSVEKHL
600
601
EEQIAKVDRE YEECMSEDLS ENIKEIRDKY EKKATLIKSS EE        
642
 

Show the unformatted sequence.

Checksums:
CRC64:6A82DA4D8B77ECDC
MD5:0118471408167cfb18b4339d76301ead

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DUF5595 213 - 268 3IZ0 C 213 - 268 Show 3D Structure View in InterPro
E 213 - 268 Show 3D Structure View in InterPro
213 - 285 2VE7 A 213 - 285 Show 3D Structure View in InterPro
B 213 - 285 Show 3D Structure View in InterPro
Ndc80_HEC 80 - 202 2VE7 A 80 - 202 Show 3D Structure View in InterPro
B 80 - 202 Show 3D Structure View in InterPro
3IZ0 C 80 - 202 Show 3D Structure View in InterPro
E 80 - 202 Show 3D Structure View in InterPro
82 - 195 2IGP A 82 - 195 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;