Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IKKB_HUMAN (O14920)

Summary

This is the summary of UniProt entry IKKB_HUMAN (O14920).

Description: Inhibitor of nuclear factor kappa-B kinase subunit beta EC=2.7.11.10
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 756 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam Pkinase 15 297
low_complexity n/a 255 266
disorder n/a 338 341
disorder n/a 373 374
Pfam IKBKB_SDD 389 663
disorder n/a 400 401
disorder n/a 408 410
disorder n/a 555 559
coiled_coil n/a 560 580
disorder n/a 574 583
disorder n/a 585 586
disorder n/a 671 706
Pfam IKKbetaNEMObind 706 742
disorder n/a 738 739
disorder n/a 752 756

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O14920. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSWSPSLTTQ TCGAWEMKER LGTGGFGNVI RWHNQETGEQ IAIKQCRQEL
50
51
SPRNRERWCL EIQIMRRLTH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ
100
101
GGDLRKYLNQ FENCCGLREG AILTLLSDIA SALRYLHENR IIHRDLKPEN
150
151
IVLQQGEQRL IHKIIDLGYA KELDQGSLCT SFVGTLQYLA PELLEQQKYT
200
201
VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE VDIVVSEDLN
250
251
GTVKFSSSLP YPNNLNSVLA ERLEKWLQLM LMWHPRQRGT DPTYGPNGCF
300
301
KALDDILNLK LVHILNMVTG TIHTYPVTED ESLQSLKARI QQDTGIPEED
350
351
QELLQEAGLA LIPDKPATQC ISDGKLNEGH TLDMDLVFLF DNSKITYETQ
400
401
ISPRPQPESV SCILQEPKRN LAFFQLRKVW GQVWHSIQTL KEDCNRLQQG
450
451
QRAAMMNLLR NNSCLSKMKN SMASMSQQLK AKLDFFKTSI QIDLEKYSEQ
500
501
TEFGITSDKL LLAWREMEQA VELCGRENEV KLLVERMMAL QTDIVDLQRS
550
551
PMGRKQGGTL DDLEEQAREL YRRLREKPRD QRTEGDSQEM VRLLLQAIQS
600
601
FEKKVRVIYT QLSKTVVCKQ KALELLPKVE EVVSLMNEDE KTVVRLQEKR
650
651
QKELWNLLKI ACSKVRGPVS GSPDSMNASR LSQPGQLMSQ PSTASNSLPE
700
701
PAKKSEELVA EAHNLCTLLE NAIQDTVREQ DQSFTALDWS WLQTEEEEHS
750
751
CLEQAS                                                
756
 

Show the unformatted sequence.

Checksums:
CRC64:F9CADF671AE9E14E
MD5:8b8f623e72b89495992f31c451969829

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
IKBKB_SDD 389 - 663 4E3C A 389 - 663 Jmol OpenAstexViewer
B 389 - 663 Jmol OpenAstexViewer
C 389 - 663 Jmol OpenAstexViewer
D 389 - 663 Jmol OpenAstexViewer
E 389 - 663 Jmol OpenAstexViewer
F 389 - 663 Jmol OpenAstexViewer
4KIK A 389 - 663 Jmol OpenAstexViewer
B 389 - 663 Jmol OpenAstexViewer
IKKbetaNEMObind 706 - 730 3BRT A 706 - 730 Jmol OpenAstexViewer
C 706 - 730 Jmol OpenAstexViewer
706 - 742 3BRV A 706 - 742 Jmol OpenAstexViewer
C 706 - 742 Jmol OpenAstexViewer
Pkinase 15 - 297 4KIK A 15 - 297 Jmol OpenAstexViewer
B 15 - 297 Jmol OpenAstexViewer
16 - 297 4E3C A 16 - 297 Jmol OpenAstexViewer
B 16 - 297 Jmol OpenAstexViewer
C 16 - 297 Jmol OpenAstexViewer
D 16 - 297 Jmol OpenAstexViewer
E 16 - 297 Jmol OpenAstexViewer
F 16 - 297 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.