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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IKKA_HUMAN (O15111)

Summary

This is the summary of UniProt entry IKKA_HUMAN (O15111).

Description: Inhibitor of nuclear factor kappa-B kinase subunit alpha EC=2.7.11.10
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 745 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 14
low_complexity n/a 2 13
Pfam Pkinase 15 298
disorder n/a 339 340
Pfam IKBKB_SDD 386 659
disorder n/a 678 684
disorder n/a 693 698
Pfam IKKbetaNEMObind 707 743
disorder n/a 735 736

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O15111. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MERPPGLRPG AGGPWEMRER LGTGGFGNVC LYQHRELDLK IAIKSCRLEL
50
51
STKNRERWCH EIQIMKKLNH ANVVKACDVP EELNILIHDV PLLAMEYCSG
100
101
GDLRKLLNKP ENCCGLKESQ ILSLLSDIGS GIRYLHENKI IHRDLKPENI
150
151
VLQDVGGKII HKIIDLGYAK DVDQGSLCTS FVGTLQYLAP ELFENKPYTA
200
201
TVDYWSFGTM VFECIAGYRP FLHHLQPFTW HEKIKKKDPK CIFACEEMSG
250
251
EVRFSSHLPQ PNSLCSLVVE PMENWLQLML NWDPQQRGGP VDLTLKQPRC
300
301
FVLMDHILNL KIVHILNMTS AKIISFLLPP DESLHSLQSR IERETGINTG
350
351
SQELLSETGI SLDPRKPASQ CVLDGVRGCD SYMVYLFDKS KTVYEGPFAS
400
401
RSLSDCVNYI VQDSKIQLPI IQLRKVWAEA VHYVSGLKED YSRLFQGQRA
450
451
AMLSLLRYNA NLTKMKNTLI SASQQLKAKL EFFHKSIQLD LERYSEQMTY
500
501
GISSEKMLKA WKEMEEKAIH YAEVGVIGYL EDQIMSLHAE IMELQKSPYG
550
551
RRQGDLMESL EQRAIDLYKQ LKHRPSDHSY SDSTEMVKII VHTVQSQDRV
600
601
LKELFGHLSK LLGCKQKIID LLPKVEVALS NIKEADNTVM FMQGKRQKEI
650
651
WHLLKIACTQ SSARSLVGSS LEGAVTPQTS AWLPPTSAEH DHSLSCVVTP
700
701
QDGETSAQMI EENLNCLGHL STIIHEANEE QGNSMMNLDW SWLTE     
745
 

Show the unformatted sequence.

Checksums:
CRC64:4EA55C6FFC66FA16
MD5:446ab468a56cbcddbfa576a3fe4f3a6a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
IKBKB_SDD 386 - 659 5EBZ A 386 - 659 Jmol OpenAstexViewer
B 386 - 659 Jmol OpenAstexViewer
C 386 - 659 Jmol OpenAstexViewer
D 386 - 659 Jmol OpenAstexViewer
E 386 - 659 Jmol OpenAstexViewer
F 386 - 659 Jmol OpenAstexViewer
G 386 - 659 Jmol OpenAstexViewer
H 386 - 659 Jmol OpenAstexViewer
I 386 - 659 Jmol OpenAstexViewer
J 386 - 659 Jmol OpenAstexViewer
K 386 - 659 Jmol OpenAstexViewer
L 386 - 659 Jmol OpenAstexViewer
5TQW A 386 - 659 Jmol OpenAstexViewer
B 386 - 659 Jmol OpenAstexViewer
5TQX A 386 - 659 Jmol OpenAstexViewer
B 386 - 659 Jmol OpenAstexViewer
5TQY A 386 - 659 Jmol OpenAstexViewer
B 386 - 659 Jmol OpenAstexViewer
IKKbetaNEMObind 732 - 743 3BRT A 731 - 742 Jmol OpenAstexViewer
C 731 - 742 Jmol OpenAstexViewer
Pkinase 15 - 298 5EBZ A 15 - 298 Jmol OpenAstexViewer
B 15 - 298 Jmol OpenAstexViewer
C 15 - 298 Jmol OpenAstexViewer
D 15 - 298 Jmol OpenAstexViewer
E 15 - 298 Jmol OpenAstexViewer
F 15 - 298 Jmol OpenAstexViewer
G 15 - 298 Jmol OpenAstexViewer
H 15 - 298 Jmol OpenAstexViewer
I 15 - 298 Jmol OpenAstexViewer
J 15 - 298 Jmol OpenAstexViewer
K 15 - 298 Jmol OpenAstexViewer
L 15 - 298 Jmol OpenAstexViewer
5TQW A 15 - 298 Jmol OpenAstexViewer
B 15 - 298 Jmol OpenAstexViewer
5TQX A 15 - 298 Jmol OpenAstexViewer
B 15 - 298 Jmol OpenAstexViewer
5TQY A 15 - 298 Jmol OpenAstexViewer
B 15 - 298 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.