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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: NPHP1_HUMAN (O15259)

Summary

This is the summary of UniProt entry NPHP1_HUMAN (O15259).

Description: Nephrocystin-1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 732 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 3 19
coiled_coil n/a 3 37
disorder n/a 21 40
disorder n/a 48 50
coiled_coil n/a 49 72
disorder n/a 60 91
coiled_coil n/a 75 95
disorder n/a 103 162
low_complexity n/a 115 147
Pfam SH3_1 158 204
disorder n/a 193 194
disorder n/a 201 243
low_complexity n/a 210 232
low_complexity n/a 224 239
disorder n/a 288 292
low_complexity n/a 548 566
disorder n/a 701 704

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O15259. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLARRQRDPL QALRRRNQEL KQQVDSLLSE SQLKEALEPN KRQHIYQRCI
50
51
QLKQAIDENK NALQKLSKAD ESAPVANYNQ RKEEEHTLLD KLTQQLQGLA
100
101
VTISRENITE VGAPTEEEEE SESEDSEDSG GEEEDAEEEE EEKEENESHK
150
151
WSTGEEYIAV GDFTAQQVGD LTFKKGEILL VIEKKPDGWW IAKDAKGNEG
200
201
LVPRTYLEPY SEEEEGQESS EEGSEEDVEA VDETADGAEV KQRTDPHWSA
250
251
VQKAISEAGI FCLVNHVSFC YLIVLMRNRM ETVEDTNGSE TGFRAWNVQS
300
301
RGRIFLVSKP VLQINTVDVL TTMGAIPAGF RPSTLSQLLE EGNQFRANYF
350
351
LQPELMPSQL AFRDLMWDAT EGTIRSRPSR ISLILTLWSC KMIPLPGMSI
400
401
QVLSRHVRLC LFDGNKVLSN IHTVRATWQP KKPKTWTFSP QVTRILPCLL
450
451
DGDCFIRSNS ASPDLGILFE LGISYIRNST GERGELSCGW VFLKLFDASG
500
501
VPIPAKTYEL FLNGGTPYEK GIEVDPSISR RAHGSVFYQI MTMRRQPQLL
550
551
VKLRSLNRRS RNVLSLLPET LIGNMCSIHL LIFYRQILGD VLLKDRMSLQ
600
601
STDLISHPML ATFPMLLEQP DVMDALRSSW AGKESTLKRS EKRDKEFLKS
650
651
TFLLVYHDCV LPLLHSTRLP PFRWAEEETE TARWKVITDF LKQNQENQGA
700
701
LQALLSPDGV HEPFDLSEQT YDFLGEMRKN AV                   
732
 

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Checksums:
CRC64:270125F56F2C50F7
MD5:7a6e4378beac9f7e71c0a059e993db9c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SH3_1 158 - 204 1S1N A 158 - 204 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.