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9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SHIP2_HUMAN (O15357)

Summary

This is the summary of UniProt entry SHIP2_HUMAN (O15357).

Description: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 EC=3.1.3.86
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1258 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 1 19
Pfam SH2 21 102
low_complexity n/a 27 37
disorder n/a 82 83
disorder n/a 113 180
low_complexity n/a 117 136
low_complexity n/a 155 174
disorder n/a 197 199
disorder n/a 201 215
disorder n/a 243 253
low_complexity n/a 259 271
disorder n/a 286 304
low_complexity n/a 289 300
Pfam Exo_endo_phos 429 718
disorder n/a 864 876
disorder n/a 897 1118
low_complexity n/a 932 959
low_complexity n/a 962 976
low_complexity n/a 997 1011
low_complexity n/a 1034 1045
low_complexity n/a 1047 1066
low_complexity n/a 1072 1090
low_complexity n/a 1087 1104
disorder n/a 1120 1193
Pfam SAM_1 1200 1258
disorder n/a 1233 1244

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O15357. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASACGAPGP GGALGSQAPS WYHRDLSRAA AEELLARAGR DGSFLVRDSE
50
51
SVAGAFALCV LYQKHVHTYR ILPDGEDFLA VQTSQGVPVR RFQTLGELIG
100
101
LYAQPNQGLV CALLLPVEGE REPDPPDDRD ASDGEDEKPP LPPRSGSTSI
150
151
SAPTGPSSPL PAPETPTAPA AESAPNGLST VSHDYLKGSY GLDLEAVRGG
200
201
ASHLPHLTRT LATSCRRLHS EVDKVLSGLE ILSKVFDQQS SPMVTRLLQQ
250
251
QNLPQTGEQE LESLVLKLSV LKDFLSGIQK KALKALQDMS STAPPAPQPS
300
301
TRKAKTIPVQ AFEVKLDVTL GDLTKIGKSQ KFTLSVDVEG GRLVLLRRQR
350
351
DSQEDWTTFT HDRIRQLIKS QRVQNKLGVV FEKEKDRTQR KDFIFVSARK
400
401
REAFCQLLQL MKNKHSKQDE PDMISVFIGT WNMGSVPPPK NVTSWFTSKG
450
451
LGKTLDEVTV TIPHDIYVFG TQENSVGDRE WLDLLRGGLK ELTDLDYRPI
500
501
AMQSLWNIKV AVLVKPEHEN RISHVSTSSV KTGIANTLGN KGAVGVSFMF
550
551
NGTSFGFVNC HLTSGNEKTA RRNQNYLDIL RLLSLGDRQL NAFDISLRFT
600
601
HLFWFGDLNY RLDMDIQEIL NYISRKEFEP LLRVDQLNLE REKHKVFLRF
650
651
SEEEISFPPT YRYERGSRDT YAWHKQKPTG VRTNVPSWCD RILWKSYPET
700
701
HIICNSYGCT DDIVTSDHSP VFGTFEVGVT SQFISKKGLS KTSDQAYIEF
750
751
ESIEAIVKTA SRTKFFIEFY STCLEEYKKS FENDAQSSDN INFLKVQWSS
800
801
RQLPTLKPIL ADIEYLQDQH LLLTVKSMDG YESYGECVVA LKSMIGSTAQ
850
851
QFLTFLSHRG EETGNIRGSM KVRVPTERLG TRERLYEWIS IDKDEAGAKS
900
901
KAPSVSRGSQ EPRSGSRKPA FTEASCPLSR LFEEPEKPPP TGRPPAPPRA
950
951
APREEPLTPR LKPEGAPEPE GVAAPPPKNS FNNPAYYVLE GVPHQLLPPE
1000
1001
PPSPARAPVP SATKNKVAIT VPAPQLGHHR HPRVGEGSSS DEESGGTLPP
1050
1051
PDFPPPPLPD SAIFLPPSLD PLPGPVVRGR GGAEARGPPP PKAHPRPPLP
1100
1101
PGPSPASTFL GEVASGDDRS CSVLQMAKTL SEVDYAPAGP ARSALLPGPL
1150
1151
ELQPPRGLPS DYGRPLSFPP PRIRESIQED LAEEAPCLQG GRASGLGEAG
1200
1201
MSAWLRAIGL ERYEEGLVHN GWDDLEFLSD ITEEDLEEAG VQDPAHKRLL
1250
1251
LDTLQLSK                                              
1258
 

Show the unformatted sequence.

Checksums:
CRC64:D76B5AA8ACDE8CBA
MD5:694d9c78ba544b74145822ea7be886ab

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Exo_endo_phos 429 - 718 3NR8 A 429 - 718 Jmol OpenAstexViewer
B 429 - 718 Jmol OpenAstexViewer
4A9C A 429 - 718 Jmol OpenAstexViewer
B 429 - 718 Jmol OpenAstexViewer
5OKM A 429 - 718 Jmol OpenAstexViewer
B 429 - 718 Jmol OpenAstexViewer
C 429 - 718 Jmol OpenAstexViewer
D 429 - 718 Jmol OpenAstexViewer
E 429 - 718 Jmol OpenAstexViewer
F 429 - 718 Jmol OpenAstexViewer
G 429 - 718 Jmol OpenAstexViewer
H 429 - 718 Jmol OpenAstexViewer
5OKN A 429 - 718 Jmol OpenAstexViewer
B 429 - 718 Jmol OpenAstexViewer
C 429 - 718 Jmol OpenAstexViewer
D 429 - 718 Jmol OpenAstexViewer
E 429 - 718 Jmol OpenAstexViewer
F 429 - 718 Jmol OpenAstexViewer
G 429 - 718 Jmol OpenAstexViewer
H 429 - 718 Jmol OpenAstexViewer
5OKO A 429 - 718 Jmol OpenAstexViewer
B 429 - 718 Jmol OpenAstexViewer
5OKP A 429 - 718 Jmol OpenAstexViewer
SAM_1 1200 - 1258 2K4P A 28 - 86 Jmol OpenAstexViewer
2KSO B 28 - 86 Jmol OpenAstexViewer
SH2 21 - 102 2MK2 A 13 - 94 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.